Results 41 to 50 of about 85,664 (274)

Rodent animal models of delayed bone healing and non-union formation: a comprehensive review [PDF]

European Cells & Materials, 2013
Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain a major clinical challenge. Animal models are needed to study the complex process of normal and impaired fracture healing and to develop ...
P Garcia, T Histing, JH Holstein, M Klein, MW Laschke, R Matthys, A Ignatius, B Wildemann, J Lienau, A Peters, B Willie, G Duda, L Claes, T Pohlemann, MD Menger   +14 more
doaj  

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Fortified Withaferin A accelerates the transition from fibrovascular to bone remodeling phase during endochondral bone formation to promote ossification

Frontiers in Endocrinology
IntroductionThis study shows that Fortified Withaferin A (FWA, 10% w/w) accelerates bone healing, advancing from the fibrovascular to bone remodeling stage within 12 days, compared to the typical 23–24-day healing time in rodents.
Kunal Chutani, Kunal Chutani, Nikhil Rai, Anirban Sardar, Anirban Sardar, Anupama Yadav, Divya Rai, Divya Rai, Anuj Raj, Anuj Raj, Bhaskar Maji, Bhaskar Maji, Shikha Verma, Shikha Verma, Ashish Kumar Tripathi, Ashish Kumar Tripathi, Geeta Dhaniya, Geeta Dhaniya, Lal Hingorani, Prabhat Ranjan Mishra, Prabhat Ranjan Mishra, Ritu Trivedi, Ritu Trivedi   +22 more
doaj   +1 more source

Patient-dependent factors for fractures union failure among Riyadh population 2016

Journal of Family Medicine and Primary Care, 2020
Background: The primary care has an important role to prevent fractures and make sure of complete healing without any complications like a Malunion which arises when a fracture has healed in a non-anatomical position, and a delayed union which defined as
Mohammed Aldhafian, Faisal Alotaibi, Azam Alzahrani, Hareth Almajid, Abdullah Alamri, Ahmad Aljandal, Feras Alamri, Fares Alhawas, Amar Fathi M Khalifa   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

From Nail to Fail: Complications Encountered with Clavicle Nailing – A Series of 3 Cases

Journal of Orthopaedic Case Reports
Introduction: Clavicle fractures are common injuries and the trend from non-operative management has been now changed toward operative management.
S Udayan, S Srijay Sashaank, Mohamed Sameer, J K Giriraj   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Molecular-neurovascular mechanisms of metal implant hypersensitivity as a cause of osteosynthesis failure and delayed bone union: a clinical case study

Medičnì Perspektivi
Metal hypersensitivity is a rare but clinically significant cause of aseptic inflammation and delayed bone union after osteosynthesis. The release of nickel, cobalt, and chromium ions from metal implants induces a T-lymphocyte–mediated delayed-type ...
Ya.D. Bondarenko, M.Yu. Stroiev, M.I. Lytvynenko, M.D. Bitchuk   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source