Results 41 to 50 of about 53,293 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Polish Regional Labour Market Welfare Indicator And Its Links To Other Well-being Measures

open access: yesComparative Economic Research, 2016
We propose and construct an indicator of labour market well-being in Poland for the year 2013. The indicator is positively related to the degree of civilizational welfare, social welfare, material welfare and psychological wellbeing in Poland.
Marek Ręklewski, Maciej Ryczkowski
doaj   +1 more source

The sky's the limit? Establishing a legal delimitation of airspace and outer space [PDF]

open access: yes, 2008
The debate over the legal delimitation between air and space has been argued for over half a century. In representing the positions of those concerned one can show the need for a boundary between airspace and outer space.
Monahan, Rhys
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Species delimitation and global biosecurity

open access: yes, 2011
Species delimitation directly impacts on global biosecurity. It is a critical element in the decisions made by national governments in regard to the flow of trade and to the biosecurity measures imposed to protect countries from the threat of invasive ...
De Barro, PJ   +7 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Malapportionment in Mongolian elections: Does institutional structure matter?

open access: yesCogent Social Sciences, 2023
This article examines malapportionment in Mongolia from the introduction of a unicameral parliament in 1992 to the parliamentary elections in 2016. We especially address the question whether the level of malapportionment was significantly influenced by ...
Pavel Maškarinec
doaj   +1 more source

Issues and problems in Mediterranean maritime boundary delimitation : a geographical analysis. [PDF]

open access: yes, 1993
In 2 volsAvailable from British Library Document Supply Centre- DSC:DX179488 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Langford, Stephen Roy, Langford, S.R
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

ENERGY ISSUES AS THE TRIGGER OF FORMATION OF AN INTERNATIONAL REGIME OF THE CASPIAN SEA

open access: yesVestnik MGIMO-Universiteta, 2018
The research object of the article is a development of the international regime of the Caspian Sea after the collapse of the Soviet Union in 1991 and increase in the number of the Caspian Littoral States, which transformed the former “closed” Soviet ...
I. S. Rozhkov
doaj   +1 more source

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