Results 111 to 120 of about 1,852,348 (320)

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Impact of violence against women on severe acute maternal morbidity in the intensive care unit, including neonatal outcomes: a case–control study protocol in a tertiary healthcare facility in Lima, Peru [PDF]

, 2018
Introduction Preventing and reducing violence against women (VAW) and maternal mortality are Sustainable Development Goals. Worldwide, the maternal mortality ratio has fallen about 44% in the last 25 years, and for one maternal death there are many women
Ayala Quintanilla, Beatriz Paulina, McDonald, Susan J, Pollock, Wendy E, Taft, Angela J   +3 more
core   +3 more sources

Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis

British medical journal, 2016
Objective To assess the effect of treatment for cervical intraepithelial neoplasia (CIN) on obstetric outcomes and to correlate this with cone depth and comparison group used. Design Systematic review and meta-analysis.
M. Kyrgiou, A. Athanasiou, M. Paraskevaidi, A. Mitra, I. Kalliala, P. Martin-Hirsch, M. Arbyn, P. Bennett, E. Paraskevaidis   +8 more
semanticscholar   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Tracking and debriefing birth data at scale: A mobile phone application to improve obstetric and neonatal care in Bihar, India. [PDF]

, 2018
AimThis analysis assessed changes over time in skill and knowledge related to the use of evidence-based practices associated with quality of maternal and neonatal care during a nurse midwife mentoring intervention at primary health clinics (PHCs) in ...
Bagchi, Kingshuk, Christmas, Amelia, Cohen, Susanna R, Das, Aritra, Dyer, Jessica, Mahapatra, Tanmay, Ranjan, Vikash, Shah, Malay Bharat, Spindler, Hilary, Sterling, Mona, Walker, Dilys   +10 more
core   +2 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Obstetrical and perinatal outcomes in patients with or without obstetric analgesia during labor

Iatreia, 2016
Objective: To describe and compare the obstetric and perinatal outcomes in patients with or without obstetric analgesia during labor, and to determine whether such analgesia is associated with adverse maternal or perinatal outcomes.
Piedrahíta-Gutiérrez, Dany Leandro, España-Chamorro, Jhoana Andrea, Piedrahíta-Gutiérrez, Wilmar Eduardo, López-Clavijo, Carlos Alberto, Henao-Flórez, Rodrigo Eduardo   +4 more
doaj   +1 more source

Household costs of healthcare during pregnancy, delivery, and the postpartum period : a case study from Matlab, Bangladesh [PDF]

, 2006
A household survey was undertaken in Matlab, a rural area of Bangladesh, to estimate the costs incurred during pregnancy, delivery, and the postpartum period for women delivering at home and in a health facility.
Blum, Lauren S., Borghi, Josephine, Hoque, Mohammad Enamul, Nazme, Sabina, Ronsmans, Carine   +4 more
core   +3 more sources

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
A Brady, AL Rickards, AT Bhutta, BE Stephens, CM McCarton, D Wolke, Daniel F. MacKay, G Wiener, Gordon C. S. Smith, I Kirkegaard, J Briscoe, J Cuzick, Jill P. Pell, LA Foulder-Hughes, M Lagerstrom, M Ornstein, MG Eide, MJ Davidoff, P Royston, PJ Anderson, RG Record, Richard Dobbie, S Campbell, S Yang, SK Cole, Tze Kin Lau   +25 more
core   +4 more sources

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source