Results 191 to 200 of about 1,791,803 (246)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Impact of next-generation delivery assist catheters and crossing strategy on reperfusion success in aspiration thrombectomy.

Interv Neuroradiol
Nogueira RG, Fitzgerald S, Murillo Artigues M, Adedeji AR, Mullins L, Thornton J.   +5 more
europepmc   +1 more source

The new era of siRNA therapy: Advances in cancer treatment. [PDF]

Clin Transl Med
Zhang Z, Yu M, Hu G, Gan Y.
europepmc   +1 more source

Numerical Studies of Influencing Factors on the Homogeneity of the Powder Mixture during the Powder Spreading Process of Powder Bed Fusion–Laser Beam/Metal

Advanced Engineering Materials, EarlyView.
AISI 304L stainless steel powder is mixed with silicon nitride (Si3N4) powder and processed by PBF‐LB/M, allowing partial retention of Si3N4. The numerical approach effectively predicts the Si3N4 powder homogeneity and N content distribution on the powder bed. Recent studies have focused on the alloying of nitrogen (N) in high‐alloy stainless steels by
Yuanbin Deng, Ziping Sang, Jiali Zhang, Felix Radtke, Louis Becker, Simone Herzog, Sebastian Weber, Christoph Broeckmann   +7 more
wiley   +1 more source

Correction: Transitioning from the Safety of the Womb to the Outside World for Neonates with Life-Threatening Cardiovascular Conditions: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Procedure. [PDF]

Pediatr Cardiol
Padiyath A, Lynch JM, Montenegro LM, Nicolson SC, Nelson O, Szwast AL, Shillingford AJ, Falkensammer CB, Savla JJ, Moldenhauer J, Khalek N, Rychik J.   +11 more
europepmc   +1 more source

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

Advanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani, Aditi Singh, Behnam Ashrafi   +2 more
wiley   +1 more source

Fatal Progression of Vulvar Cancer in Pregnancy: A Case Report on Delayed Intervention. [PDF]

Am J Case Rep
Hapsari K, Suryawan AZ, Harsono AB, Winarno GNA, Usman HA.   +4 more
europepmc   +1 more source

Assessing the Ecological Value: Monetizing Process Innovations in Tailored Forming

Advanced Engineering Materials, EarlyView.
This article introduces a method for evaluating the sustainability of innovations, even with limited data. The method is illustrated through an analysis of the “Tailored Forming” technology, which explores the impact of sustainability on economic value added.
Jonas Schneider, Jan Westing, Matthias Schmidt, Peter Nyhuis, Vivian Katharina Kuprat   +4 more
wiley   +1 more source

Mechanisms of Increasing Weld Depth during Temporal Power Modulation in High‐Power Laser Beam Welding

Advanced Engineering Materials, EarlyView.
Temporal power modulation increases weld depth in high‐power laser beam welding of dissimilar round bars by nearly 20% compared to same average continuously welded welding power. The mechanism of action also applies to sheet welding and depends on the inertia of keyhole depth for the modulated laser beam power.
Jan Grajczak, David Reynders, Christian Nowroth, Jens Twiefel, Jörg Wallaschek, Sarah Nothdurft, Jörg Hermsdorf, Stefan Kaierle   +7 more
wiley   +1 more source

Potential Applications of Natural Components of Traditional Chinese Medicine Delivery via Nanoparticle Drug Delivery Systems in the Treatment of Alzheimer's Disease. [PDF]

Int J Nanomedicine
Lai G, Wu H, Yang K, Hu K, Zhao W, Chen X, Li J, Wang H, Lv Z, Xie G, Wu X.   +10 more
europepmc   +1 more source