Results 41 to 50 of about 2,685,673 (317)

Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells

open access: yesBiomedicines, 2022
Oligonucleotide therapeutics, antisense oligonucleotides (ASOs) and short interfering RNA (siRNA) are short synthetic nucleic acid molecules with a promising potential to treat a wide range of diseases.
Mauro Sousa de Almeida   +3 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

Gastroretentive microparticles for drug delivery applications [PDF]

open access: yes, 2011
Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small ...
Conway, Barbara R   +5 more
core   +1 more source

Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging

open access: yesNanomaterials, 2021
Functionalized nanomaterials of various categories are essential for developing cancer nano-theranostics for brain diseases; however, some limitations exist in their effectiveness and clinical translation, such as toxicity, limited tumor penetration, and
Ramar Thangam   +2 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker   +11 more
wiley   +1 more source

Occurrence of exotic carriers arbovirus fevers – new insufficiently estimated biological threat to southern regions of Russia

open access: yesЖурнал инфектологии, 2014
Delivery of originators of infectious and parasitic illnesses on new territories can pass by means of mosquitoes which in modern conditions extend quickly. Getting on new territories they take roots and provide transfer of this or that originator.
V. P. Sergiev
doaj   +1 more source

Coronaeconomics: a New World After the Pandemic

open access: yesInformaciâ i Innovacii, 2020
The multifactorial systemic crisis resulting from the COVID-19 coronavirus pandemic is causing critical changes in a number of sectors of the world economy. The author analyses the opinions of leading domestic and foreign experts on this topic.
A. S. Genkin
doaj   +1 more source

A Comparative Contemplation on the Rule regarding the Destruction of the Object of the Sale before Delivery in Article 387 of the Iranian Civil Code: A Comparative Study of Imamiah Jurisprudence, Iranian Law and CISG [PDF]

open access: yesپژوهش تطبیقی حقوق اسلام و غرب, 2017
Article 387 of the Iranian Civil Code, following the Imamiah thinkers, has prescribed the termination of sale in the case of the destruction of sold object before delivery to buyer without seller's encroachment or negligence. Now, the question is whether
Sayyed Abdol Motalleb Ahmad Zade Bazzaz   +2 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Poly[N-(2-aminoethyl)ethyleneimine] as a New Non-Viral Gene Delivery Carrier: The Effect of Two Protonatable Nitrogens in the Monomer Unit on Gene Delivery Efficiency

open access: yes, 2014
Purpose. The aim of this study was to investigate the in vitro gene delivery efficiency of poly[N-(2-aminoethyl)ethylene-imine](PAEEI), a polymer with a linear Polyethyleneimine (LPEI) backbone and with aminoethyl side groups that has two protonatable ...
Esfahani, Mohammad Hossein Nasr   +12 more
core   +1 more source

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