Results 61 to 70 of about 11,726 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Digital OFDM-PON Based on Delta–Sigma Modulation Employing Binary IM-DD Channels

IEEE Photonics Journal, 2017
In this paper, a delta–sigma modulation is proposed for the orthogonal frequency division multiplexed-passive optical network (OFDM-PON) to enable transmission of OFDM signals via binary intensity modulation and direct detection (IM-DD) channels ...
Cai Li, Rong Hu, Haibo B. Li, Ming Luo, Qi Yang, Shaohua Yu   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Efficient single-bit ternary digital filtering using sigma-delta modulator

, 2004
Efficient filtering of sigma-delta bit-streams using a finite-impulse response (FIR)-like digital filter is presented. The filter combines a lowpass sigma-delta modulator system and a ternary FIR filter.
Thompson, Adam C., P. O'Shea, Steele, Brenton R., Hussain, Zahir M., B.R. Steele, A.C. Thompson, Z.M. Hussain, O'Shea, Peter J.   +7 more
core   +1 more source

A Low-Power Delta-Sigma Capacitance-to-Digital Converter for Capacitive Sensors

IEEE Access, 2019
This paper proposes a low-power delta-sigma capacitance-to-digital converter (CDC) for a capacitive sensor. The input of the capacitive sensor employs a zoomed-in technique with the offset capacitor to extend the input capacitance range. The proposed CDC
Rongshan Wei, Wanjin Wang, Xiaoxia Xiao, Qunchao Chen   +3 more
doaj   +1 more source

Continuous time delta sigma modulators with reduced clock jitter sensitivity [PDF]

, 2006
In this paper, a technique and method is presented to suppress the effect of clock-jitter in continuous-time delta-sigma modulators with switched-current (current-steering) digital to analogue converters.
Zare-Hoseini, H., Kale, I.
core   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

Advanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham, Chenyu Wen, Mohammad Hadi Khaksaran, Won‐Yong Lee, Javier Cruz, Klas Hjort, Dongping Wu, Shi‐Li Zhang   +7 more
wiley   +1 more source

Surface Tension Measurement of Ti‐6Al‐4V by Falling Droplet Method in Oxygen‐Free Atmosphere

Advanced Engineering Materials, EarlyView.
In this article, the temperature‐dependent surface tension of free falling, oscillating Ti‐6Al‐4V droplets is investigated in both argon and monosilane doped, oxygen‐free atmosphere. Droplet temperature and oscillation are captured with one single high‐speed camera, and the surface tension is calculated with Rayleigh's formula.
Johannes May, Finn‐Lennard Janthur, Lena Kreie, Michael Müller, Sarah Seffer, Nick Schwarz, Jörg Hermsdorf, Thomas Hassel, Stefan Kaierle, Ludger Overmeyer   +9 more
wiley   +1 more source

Design of a 1-bit MEMS Gyroscope using the Model Predictive Control Approach

Sensors, 2019
In this paper, a bi-level Delta-Sigma modulator-based MEMS gyroscope design is presented based on a Model Predictive Control (MPC) approach. The MPC is popular because of its capability of handling hard constraints.
Xiaofeng Wu, Zhicheng Xie, Xueliang Bai, Trevor Kwan   +3 more
doaj   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source