Results 141 to 150 of about 20,633 (240)

Human iPSC-derived airway models enable comparative analysis of SARS-CoV-2 infection in healthy and COPD bronchial epithelium. [PDF]

iScience
Morichon L, Swain J, Gros N, Nasri A, Foisset F, Galisot G, Racine V, Assou S, Bourdin A, De Vos J, Muriaux D.   +10 more
europepmc   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Effects of hemodialysis on hemoglobin oxygen affinity and cardiac function. [PDF]

Clin Kidney J
Sharma S, Nguyen KL, Salusky IB, Ganz T, Ix JH.   +4 more
europepmc   +1 more source

Changes in choroidal and retinal thickness 6 months before and during 18 months of orthokeratology lens treatment in myopic children

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate changes in choroidal and retinal thickness before and during myopia control treatment with orthokeratology lenses (OKL) in myopic children. Methods This was a sub‐study of CONTROL and CONTROL2 studies. The present study was a 2‐year, prospective, single‐group interventional study consisting of a 6‐month pre‐treatment ...
P. O. Hansen, F. Møller, T. M. Jakobsen
wiley   +1 more source

Echocardiographic Predictors of Ventricular Arrhythmias Post-Automatic Implantable Cardioverter-Defibrillator Implantation. [PDF]

J Cardiovasc Dev Dis
Harapoz M, Zochowski YSA, Trivedi SJ, Kumar S, Thomas L.   +4 more
europepmc   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

A multifaceted clinical portrait of Ebstein's anomaly: a case series. [PDF]

Eur Heart J Case Rep
Vlachakis PK, Nyktari E, Oikonomou G, Apostolos A, Sideris S, Toutouzas K, Tsioufis C, Drakopoulou M.   +7 more
europepmc   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Implant Placement and Immediate Provisionalization After Alveolar Ridge Reconstruction in the Aesthetic Zone Using a Digital Workflow: A 1‐Year Prospective Case Series Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Introduction In single‐tooth replacement in the aesthetic zone, extensive bone defects require alveolar ridge reconstruction. A digital workflow involving CBCT and intraoral optical scanning enables a three‐dimensional assessment, prosthetically driven implant positioning, computer‐assisted implant surgery, and prefabrication of a temporary ...
Vincent J. J. Donker, Henny J. A. Meijer, Arjan Vissink, Gerry M. Raghoebar   +3 more
wiley   +1 more source

Effect of Different Irrigation Activation Techniques on Smear Layer Removal in Root Canal Treatment. [PDF]

J Pharm Bioallied Sci
Panda B, Panda S, Hota S, Dass D, Arya A, Marwaha J.   +5 more
europepmc   +1 more source