Results 151 to 160 of about 20,633 (240)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

open access: yesCell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao   +11 more
wiley   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

open access: yesThe FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson   +5 more
wiley   +1 more source

How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis? [PDF]

open access: yesMicroPubl Biol
Hosseini Moghadam M   +10 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

open access: yesThe FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak   +10 more
wiley   +1 more source

The intracellular domains of the DSL ligands Serrate and Delta provide different activities. [PDF]

open access: yesCell Commun Signal
Seib E   +7 more
europepmc   +1 more source

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

open access: yesThe FEBS Journal, EarlyView.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani   +8 more
wiley   +1 more source

Morphology of the Physiological Foramen: A Systematic Review. [PDF]

open access: yesDent J (Basel)
Wolf TG   +4 more
europepmc   +1 more source

A Common Reference Material for Mass‐Dependent Sn Isotope Compositions: An Inter‐Laboratory Calibration Approach

open access: yesGeostandards and Geoanalytical Research, EarlyView.
Key Points We recommend using the notation δ122/118SnNIST SRM 3161a for mass‐dependent Sn isotope data. We derived conversion factors relative to NIST SRM 3161a for Puri Sn CEZA (0.132 ± 0.011‰), Sn Lyon (0.229 ± 0.016‰), Sn IPGP (0.162 ± 0.018‰). Tin isotope compositions are presented for SPEX CertiPrep Sn and nine USGS reference materials.
Aurélia C.E. Meister   +10 more
wiley   +1 more source

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