Results 131 to 140 of about 85,013 (191)

Acute Neuropsychiatric Decline in a Parkinson's Disease Patient with a Severe GBA1 Mutation Following Bilateral GPi Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Vijay G. Palakuzhy, Gian D. Pal, Mitra Afshari   +2 more
wiley   +1 more source

Anosmia and Upper Limb Rigidity—A Potential Phenotype of Idiopathic Normal Pressure Hydrocephalus with Cerebrospinal Fluid α‐Synuclein Seeds

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) and its association with neurodegenerative disorders is poorly understood. Objectives The aim was to determine the prevalence of α‐synuclein pathology in iNPH and its associations with clinical characteristics. Methods We used α‐synuclein seed amplification assay
Sandrina Weber, Carly M. Farris, Yihua Ma, Mohammed Dakna, Maritta Starke, Sebastian Schade, Michael Bartl, Claudia Trenkwalder, Luis Concha‐Marambio, Brit Mollenhauer   +9 more
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Cognitive and Psychiatric Adverse Effects of Foslevodopa/Foscarbidopa in Patients with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Sacha Brohée, Emmanuel Roze, David Grabli, Hélène Letrillart, Lise Mantisi, Cendrine Foucard, Elodie Hainque, Florence Cormier, Aurélie Méneret, Fabien Hauw   +9 more
wiley   +1 more source

Universal mapping and patient‐specific prior implicit neural representation for enhanced high‐resolution MRI in MRI‐guided radiotherapy

Medical Physics, EarlyView.
Abstract Background Magnetic resonance imaging (MRI), known for its superior soft tissue contrast, plays a crucial role in radiation therapy (RT). The introduction of MR‐LINAC systems enables the use of on‐board MRI for adaptive radiotherapy (ART) on the day of treatment to maximize treatment accuracy.
Yunxiang Li, Jie Deng, You Zhang
wiley   +1 more source

Elevated Bromide Levels due to Tazemetostat Therapy Treated With Salt and Water Supplementation in Two Children With Atypical Teratoid Rhabdoid Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Atypical teratoid rhabdoid tumor (ATRT) is an embryonal CNS tumor that afflicts young children. The molecular process associated with ATRT is loss of SMARCB1 or SMARCA4, which causes EZH2 overactivation. Tazemetostat hydrobromide is an EZH2 inhibitor, which has shown efficacy in the treatment of ATRT. Tazemetostat is produced as a bromide salt
Thomas J. Galletta, Stefanie W. Benoit, Justin Markham, Natasha Pillay‐Smiley, Kate Queen, Richard T. Graham   +5 more
wiley   +1 more source

Moderation Effect of Emotional Expressivity on the Associations Between Schizotypal Traits, Autistic Traits and Social Pleasure

PsyCh Journal, EarlyView.
ABSTRACT Diminished social pleasure has been reported in people with schizophrenia and autism spectrum disorder (ASD). Previous studies suggested that emotional expressivity is closely correlated with social pleasure. However, the underlying psychological mechanisms between traits related to schizophrenia and ASD, emotional expressivity, and social ...
Li‐Ying Zhang, Miao Wang, Xin‐Wei Fu, Shou‐Nuo Chen, Jie Gu, Shuai‐Biao Li, Min‐Yi Chu, Yan‐Yu Wang, Yi Wang, Raymond C. K. Chan   +9 more
wiley   +1 more source

Scenting the Hedonic Connection: Exploring the Impact of Subjective Olfactory Dysfunction on Depressive Symptoms

PsyCh Journal, EarlyView.
ABSTRACT Olfaction, often regarded as a unique chemical sensation, plays a pivotal role in shaping our quality of life and mental well‐being. Numerous studies have highlighted the significant relationship between olfactory function and depressive symptoms.
Zihan Ni, Ye Liu, Laiquan Zou, Qidong Zhang, Wu Fan, Chao Yan   +5 more
wiley   +1 more source