iNew Medicine, EarlyView.ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang +8 more
wiley +1 more source
Medical Reasoning With Large Language Models: A Systematic Review and Evaluation
iNew Medicine, EarlyView.ABSTRACT Large language models (LLMs) have achieved strong performance on medical exam–style tasks, motivating growing interest in their deployment in real‐world clinical settings. However, clinical decision‐making is inherently safety‐critical, context‐dependent, and conducted under evolving evidence.
Xiaohan Ren +6 more
wiley +1 more source
A sense of being inserted by the original self: A distinctive manifestation of delusional misidentification of the self, a case report. [PDF]
PCN RepKoreki A, Kaji M, Oi H, Onaya M.
europepmc +1 more source
The We‐Relationship as a Key to Addressing Dementia‐Related Ambiguous Loss
Journal of Applied Philosophy, EarlyView.ABSTRACT Pauline Boss describes the challenges faced by people caring for family members with dementia in terms of ambiguous loss – a condition in which the physical presence of the person with dementia coexists with their psychological absence. This article proposes the concept of we‐relationship as a key to addressing dementia‐related ambiguous loss.
Takuya Niikawa, Xue Li
wiley +1 more source
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II. [PDF]
Mol PsychiatryWang L +6 more
europepmc +1 more source
Who Am I When You're a Bot? Relational Identity and AI Companions
Journal of Applied Philosophy, EarlyView.ABSTRACT Self‐conceptions provide a framework through which we can make sense of ourselves, interpret and navigate the world, plan our lives, and relate to others. Relational influences can greatly shape them, for instance, when others react to us or offer advice. What if this ‘other’ is not a human being, but an AI?
Muriel Leuenberger
wiley +1 more source
Erotomania in Alzheimer's Dementia: A Rare but Clinically Important Association. [PDF]
CureusOdeyemi A +3 more
europepmc +1 more source
Journal of Clinical Psychology, Volume 81, Issue 6, Page 516-525, June 2025.ABSTRACT AVATAR therapy (AT) works by facilitating a ‘face‐to‐face’ dialog between the person and a digital representation (avatar) of their persecutory voice. Although there is cumulative evidence of this way of working with voices, enhancing the therapeutic focus on improved confidence and a sense of control of the voices in social situations ...
Mar Rus‐Calafell +10 more
wiley +1 more source
The specificity of the Threat/Control-Override concept in schizophrenia - new insights from a retrospective cross-sectional study of forensic homicide offenders. [PDF]
Front PsychiatryFindeis H, Strauß M, Kröber HL.
europepmc +1 more source
Alexithymia in Schizophrenia and Psychosis Vulnerability: A Systematic Review and Meta‐Analysis
Journal of Clinical Psychology, Volume 81, Issue 6, Page 410-424, June 2025.ABSTRACT Aims Disturbances involving impairments in experience and expression of affect are frequently identified in schizophrenia samples. Alexithymia underlies cognitive impairments in identification and expression of affect, further implicated in affect dysregulation.
Ercan Ozdemir +3 more
wiley +1 more source