FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
On the within-person effects of political attitudes on outgroup animosity: Evidence for Democratic-Republican asymmetry. [PDF]
PLoS OneSchul Y, Ganzach Y, Pazy A.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Time-Series Analysis of Microtopographic Evolution and Morphological Changes in Regressive Tidal Creeks via UAV-LiDAR. [PDF]
Sensors (Basel)Kim J, Yoon H, Hong I.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smart Geospatial Analytics for Maladaptation Hotspot Detection: Integrating Trajectory Classification, Random Forest, and SHAP. [PDF]
Sensors (Basel)Buasri N +4 more
europepmc +1 more source
Granular Dynamics of the Mixing Processes for Different RPM Using DEM
, 2014 This paper emphasizes on the computer simulations of the granular materials via Discrete Element Method (DEM) by using open-source software LIGGGHTS. The examined process was mixing of two granular materials distinct by colour. The different initial conditions have led to finding the best way of homogenization, but it also shows the new perspective of ...
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Study on the Falling Characteristics of Interstitial Insolubles and the Brine Flow Field Response in Salt Cavity Reservoirs Considering Particle-Fluid Interactions. [PDF]
ACS OmegaZhang H, Wang W, Wang L.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source