Results 71 to 80 of about 35,022 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Evaluation of the Efficacy of a Dentifrice Tablet to Prevent Dental Caries: A Microbial Study

Dentistry Journal
Background/Objectives: Dentifrice tablets are a new over-the-counter dentifrice form that are gaining global interest. The aim of this microbial study was to investigate the effectiveness of a dentifrice tablet (DT) containing nanohydroxyapatite (nHAP ...
Bennett Tochukwu Amaechi, Kannan Kanthaiah, Rayane Farah, Kelly Yang, Amos Chiedu Obiefuna, Parveez Ahamed Abdul-Azees, Mahalakshmi Vijayaraghavan   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Comparison of DEMs generated using different data sources at a mountain site

Facta universitatis - series: Architecture and Civil Engineering
The paper analyzes digital elevation models (DEM) of the same area based on different sources and methods of geospatial data collection. An open-source DEM was created in the mountainous area of Colus County, which is the northern part of the US state of California.
Vladimir Petrovic, Vladica Krstic, Mirko Borisov, Aleksandar Ilic, Aleksandar Dobrisavljevic   +4 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Decadal-scale assessment of sediment denudation rates in the Zhoukou River Basin, Taiwan: insights from improved DEMs of differencing based on spectral analysis

Geomatics, Natural Hazards & Risk
This study assesses sediment erosion rates in the Zhoukou River Basin in southern Taiwan over the past three decades, focusing on the impact of extreme rainfall events.
Gopal Kumar, Yu-Chang Chan, Cheng-Wei Sun, Chih-Tung Chen   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Assessing the accuracy of different open-source Digital Elevation Models (DEMs) in morphometric analysis of Kanchi River basin

Journal of Hydrology: Regional Studies
Study region: The Kanchi river basin is located in India. Study focus: The Digital Elevation Model (DEM) is an important input in morphometric analysis; however, the accuracy of DEMs has not been comprehensively assessed, particularly over the Kanchi ...
Arun Mondal, Anupam Pandey, Souvik Mondal, Sananda Kundu, Thanh Nhan Duc Tran, Venkataraman Lakshmi   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source