Results 91 to 100 of about 35,488 (267)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Land Degradation Assessment in an Olive Orchard Using Different Soil Erosion Estimation Methods

Land
Land degradation caused by soil erosion is a major challenge in Mediterranean sloping agroecosystems, where extreme weather events and conventional land management practices accelerate soil loss and threaten long-term sustainability. This study evaluates
Christos Pantazis, Panagiotis T. Nastos
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

DEM simulations: mixing of dry and wet granular material with different contact angles

Granular Matter, 2018
In solid mixing the raw materials typically differ at least in one material property, such as particle size, solid density and wetting properties, which in turn influence particle mobility. For example, smaller particles can percolate through the voids of larger ones under the influence of strain and gravity. This may produce fine particle accumulation
Schmelzle, Steffen, Nirschl, Herrmann
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Volumetric estimation of landslide-induced terrain change using conditional GAN with multi-temporal DEMs and satellite imagery

International Journal of Applied Earth Observations and Geoinformation
Estimating landslide volumes remains challenging because of the limited availability of high-resolution terrain data. Traditional methods often rely on empirical area-to-volume conversion formulas, which introduce significant uncertainties due to terrain
Yu-En Yang, Teng-To Yu
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Performance Assessment of TanDEM-X DEM for Mountain Glacier Elevation Change Detection

Remote Sensing, 2019
TanDEM-X digital elevation model (DEM) is a global DEM released by the German Aerospace Center (DLR) at outstanding resolution of 12 m. However, the procedure for its creation involves the combination of several DEMs from acquisitions spread between 2011
Julian Podgórski, Christophe Kinnard, Michał Pętlicki, Roberto Urrutia   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effects of Digital Elevation Model Resolution on Unmanned Aerial Vehicle-Based Topographic Change Detection in Human-Altered Landscapes

Drones
UAV-based topographic change detection is widely used in geoscience communities. The change detection involves comparison of two digital elevation models (DEMs) produced by UAV surveys, which are affected by the DEM resolution.
Wen Dai, Jiahui Hu, Bo Wang, Mengtian Fan, Yiyang Zhou, Mengmeng Zhang   +5 more
doaj   +1 more source