Results 51 to 60 of about 94,447 (261)

Forecast-Based Mechanisms for Demand Response

International Joint Conference on Autonomous Agents and Multiagent Systems, 2019
We study mechanisms to incentivize demand response in smart energy systems. We assume agents that can respond (reduce their demand) with some probability if they prepare prior to the realization of the demand. Both preparation and response incur costs to agents.
Methenitis, G. (author), Kaisers, Michael (author), la Poutré, J.A. (author)   +2 more
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Integrating Demand-Responsive Transportation into Smart City Strategies: Implications for Sustainable Urban Mobility in the European Union—A Systematic Literature Review and Survey Analysis

Logistics
Background: This study seeks to explore the link between smart city development and demand-responsive transport, analyze the ways of integrating demand-responsive transport into smart mobility concepts, estimate public perceptions about those phenomena ...
Patrik Eszes, László Buics
doaj   +1 more source

Optimized Consumer-Centric Demand Response

2018 Global Internet of Things Summit (GIoTS), 2018
Demand side management has focused more on centralized control and heavily depends on continuous consumer interaction, often overlooking consumer thermal and visual comfort. Distribution grid management will necessitate the active involvement of new market actors (i.e.
Konstantinos Tzanidakis, Christos Malavazos, Kostas Tsatsakis, Antonis Papanikolaou, Tasos Tsitsanis, Brendan O'Flynn   +5 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Stimuli-Responsive Nanocarriers as Next-Generation on-Demand Drug Delivery Systems for Cancer Therapy: Mechanistic Insights, Trigger Modalities, and Translational Challenges

Pharmaceutics
Chemotherapy has been used in cancer treatment for decades; however, standard chemotherapy treatments still have significant weaknesses, including collateral damage to healthy tissue, rapid development of drug resistance, and dose-limiting toxicity that ...
Ahmed Abdulkarim Y. Alaysereen, Moath Mahmoud E. Daoud, Maha Munawar Alhoda M. Bader Alhoda, Ali Husain Ali Zayer, G. Roshan Deen   +4 more
doaj   +1 more source

Performance analysis and fleet requirements of automated demand-responsive transport systems as an urban public transport service

International Journal of Transportation Science and Technology, 2018
The introduction of public transport services by fully automated vehicles can potentially change the way public transit services will be operated, as they allow shifting from rigid scheduled and route-bound services towards flexible, demand-responsive ...
Konstanze Winter, Oded Cats, Gonçalo Correia, Bart van Arem   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Vehicle scheduling optimization for demand responsive transit with flexible stops

Shenzhen Daxue xuebao. Ligong ban
Flexible stops demand responsive transit is a public transportation mode that combines fixed service stops with the ability for passengers to book at flexible stops.
SHEN Zikang, JIN Wenzhou, ZHENG Yajing
doaj   +1 more source