Results 131 to 140 of about 112,022 (343)

Design of a Demand-Responsive Transit System

, 2007
This research investigates the feasibility of offering demand-responsive transit (DRT) service to the general public in situations of low demand density. The study region is AC Transit District 2 which consists of the cities of Fremont and Newark, California.We developed a methodology to evaluate operating efficiencies of existing bus lines and line ...
Li, Yuwei, Wang, Jessica, Chen, Justin, Cassidy, Michael   +3 more
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

17-11 Evaluation of Transit Priority Treatments in Tennessee [PDF]

, 2019
Many big cities are progressively implementing transit friendly corridors especially in urban areas where traffic may be increasing at an alarming rate.
Chimba, Deo, Ikiriko, Sotonye
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Optimizing travel costs of feeder-integrated public transport system: A methodology

Transportation Research Interdisciplinary Perspectives
Canada, with a substantial contribution from the personal transport sector, is a major per capita greenhouse gas emitter. This study advocates a sustainable 3-echelon transportation system, integrating Public Transit (PuT) and demand-responsive transit ...
Mysore Narasimhamurthy Sharath, Babak Mehran, Ahmed Ashraf, Susan Grant-Muller, Ed Manley   +4 more
doaj   +1 more source

An American Conversation on the Post-2015 Development Agenda [PDF]

, 2013
In the closing months of 2013, over 1,000 Americans gathered in communities large and small to discuss the world they want in 2030. They came together to answer a call to action from Secretary-General Ban Ki-moon for every UN member state to seek public ...

core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Demand-Responsive Transit Shuttles: Who Will Use Them? [PDF]

, 2004
Large urban areas often have rail systems that rely on feeder buses to expand their service area. This paper explores the possibility of expanding access to existing rail transit systems through demand-responsive shuttles. The study analyzes the effect of several factors on an individual's willingness to use a door-to-station shuttle service.
Anspacher, David, Khattak, Asad J., Yim, Youngbin   +2 more
openaire   +1 more source