Results 131 to 140 of about 63,753 (337)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

THE HIGH-SPEED RAIL DEVELOPMENT IN THE NORTHEAST MEGAREGION OF THE UNITED STATES: A CONCEPTUAL ANALYSIS [PDF]

This paper examines the high-speed rail (HSR) development issues in the Northeast Megaregion of the United States (U.S.). Due to chronic underinvestment and a myriad of other factors, the only operational HSR in the U.S., i.e., Amtrak’s Acela Express, is
Xueming CHEN
core  

17-11 Evaluation of Transit Priority Treatments in Tennessee [PDF]

, 2019
Many big cities are progressively implementing transit friendly corridors especially in urban areas where traffic may be increasing at an alarming rate.
Chimba, Deo, Ikiriko, Sotonye
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Demand-Responsive Transit Shuttles: Who Will Use Them? [PDF]

, 2004
Large urban areas often have rail systems that rely on feeder buses to expand their service area. This paper explores the possibility of expanding access to existing rail transit systems through demand-responsive shuttles. The study analyzes the effect of several factors on an individual's willingness to use a door-to-station shuttle service.
Anspacher, David, Khattak, Asad J., Yim, Youngbin   +2 more
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Multi-objective optimization of demand responsive transit operations based on dynamic passenger requests using maximum time delay rate

Journal of Public Transportation
Demand-responsive transit (DRT) offers on-demand service for comfortable and convenient trips. Despite these advantages, efficient DRT operation requires addressing several considerations. This study resolves the conflict between passengers wanting quick
Sang-Wook Han, Sedong Moon, Dong-Kyu Kim
doaj   +1 more source

Public Bikesharing in North America During a Period of Rapid Expansion: Understanding Business Models, Industry Trends & User Impacts, MTI Report 12-29 [PDF]

, 2014
Public bikesharing—the shared use of a bicycle fleet—is an innovative transportation strategy that has recently emerged in major cities around the world, including North America.
Chan, Nelson D., Cohen, Adam P., Martin, Elliot W., Pogodzinski, Mike, Shaheen, Susan A.   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Benchmarking Best Practices of Demand Responsive Transit Systems [PDF]

, 2003
Over the past 10 years, operating expenses for Demand Responsive Transit have more than doubled as demand for this mandated service has expanded. Many advanced technologies and management practices have been proposed and implemented to improve the efficiency of the service; but, evidence for the effectiveness of these actions has been based upon ...
Dessouky, Maged, Palmer, Kurt, Abdelmaguid, Tamer   +2 more
openaire   +1 more source