Results 141 to 150 of about 112,022 (343)
THE HIGH-SPEED RAIL DEVELOPMENT IN THE NORTHEAST MEGAREGION OF THE UNITED STATES: A CONCEPTUAL ANALYSIS [PDF]
This paper examines the high-speed rail (HSR) development issues in the Northeast Megaregion of the United States (U.S.). Due to chronic underinvestment and a myriad of other factors, the only operational HSR in the U.S., i.e., Amtrak’s Acela Express, is
Xueming CHEN
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
No Californian Left Behind: Clean and Affordable Transportation Options for All Through Vehicle Replacement [PDF]
, 2014 As California focuses in on new, high-tech, best-in-class transportation strategies, it risks leaving behind an important subset of households and communities who could most benefit from the transition to a cleaner, cheaper, and more sustainable ...
Cole Wheeler, Jesse Morris, Kate Gordon
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Benchmarking Best Practices of Demand Responsive Transit Systems [PDF]
, 2003 Over the past 10 years, operating expenses for Demand Responsive Transit have more than doubled as demand for this mandated service has expanded. Many advanced technologies and management practices have been proposed and implemented to improve the efficiency of the service; but, evidence for the effectiveness of these actions has been based upon ...
Dessouky, Maged +2 more
openaire +1 more source
Is sea-basing a viable method of providing logistic support to the UK amphibious force? [PDF]
, 2000 Maritime power has traditionally been a central part of the UK’s defence planning and is well suited to supporting a wide range of military operations. The littoral area has always created problems for naval planners as most landings historically have ...
Antill, Peter D. +2 more
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FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Government Failure in Urban Transportation [PDF]
This paper assesses governmental performance in its investment, provision and regulation of urban transportation. Attention is given to public bus and rail transit and road transportation.
Clifford Winston
core
Transportation for an Aging Population: Promoting Mobility and Equity for Low-Income Seniors [PDF]
, 2018 This study explores the travel patterns, needs, and mobility problems faced by diverse low-income, inner-city older adults in Los Angeles in order to identify solutions to their mobility challenges.
Brozen, Madeline +3 more
core +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source