Results 51 to 60 of about 11,791,772 (289)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Domestic Microgrid with Optimized Home Energy Management System

Energies, 2018
Microgrid is a community-based power generation and distribution system that interconnects smart homes with renewable energy sources (RESs). Microgrid efficiently and economically generates power for electricity consumers and operates in both islanded ...
Zafar Iqbal, Nadeem Javaid, Saleem Iqbal, Sheraz Aslam, Zahoor Ali Khan, Wadood Abdul, Ahmad Almogren, Atif Alamri   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Water demand management for social justice : women, like men, have much to offer in the management of water resources [PDF]

, 2008
French version available in IDRC Digital Library: Gestion de la demande en eau, un instrument de justice sociale : les femmes, comme les hommes, ont beaucoup à offrir en matière de gestion des ressources hydriquesArabic version available in IDRC Digital ...

core   +1 more source

Demand-side management for smart grid via diffusion adaptation

IET Smart Grid, 2019
This study presents a novel fully distributed and cooperative demand side management framework based on adaptive diffusion strategy. In this approach, each customer autonomously and without any need for the global information, minimises his incommodity ...
Milad Latifi, Azam Khalili, Amir Rastegarnia, Wael M. Bazzi, Saeid Sanei   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Agent-based control for decentralised demand side management in the smart grid

, 2011
Central to the vision of the smart grid is the deployment of smart meters that will allow autonomous software agents, representing the consumers, to optimise their use of devices and heating in the smart home while interacting with the grid.
Vytelingum, Perukrishnen, Jennings, Nick, Rogers, Alex, Ramchurn, Sarvapali   +3 more
core   +1 more source

System Demand Side Management w zarządzaniu kosztami

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019
In the article the author tries to scrutinize the problem regarding Demand Side Management in energy industry. The aim of the article is to prove that demand side management can support the cost management and as a consequence the effectiveness of the ...
Marcin Wierzbiński
doaj