Results 121 to 130 of about 4,278,572 (308)

Cost–utility analysis of prophylaxis versus treatment on demand in severe hemophilia A

open access: yesClinicoEconomics and Outcomes Research, 2011
Giorgio L Colombo1,2, Sergio Di Matteo2, Maria Elisa Mancuso3, Elena Santagostino31University of Pavia, School of Pharmacy, Pavia, Italy; 2S.A.V.E. Studi Analisi Valutazioni Economiche, Milan, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis ...
Maria Elisa Mancuso   +3 more
doaj  

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Pre-Hospital Blood Products for the Care of Bleeding Trauma Patients. [PDF]

open access: yesDtsch Arztebl Int, 2023
Maegele M, Lier H, Hossfeld B.
europepmc   +1 more source

Industrial Coal Demand in China: A Provincial Analysis [PDF]

open access: yes
The general concern on the environmental implications of the rising demand for coal registered in China during the last few years has induced considerable research effort to produce accurate forecasts of China’s energy requirements.
Cristina Cattaneo   +2 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Consumers’ Demand for Pork Quality: Applying Semantic Network Analysis, May 2006 [PDF]

open access: yes, 2006
Consideration of consumers’ demand for food quality entails several aspects. Quality itself is a complex and dynamic concept, and constantly evolving technical progress may cause changes in consumers’ judgment of quality.

core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Reducing demand: a quantitative analysis of energy service demand indicators in sufficiency-oriented scenarios

open access: yesEnvironmental Research Communications
A reduction of energy service demand in all sectors is required to reach ambitious climate and other sustainability goals. A growing number of energy and climate scenarios does include detailed assumptions and quantified parameters for the reduction of ...
Frauke Wiese   +4 more
doaj   +1 more source

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