Results 61 to 70 of about 626,794 (305)

Stochastic model of forecasting spare parts demand [PDF]

open access: yesVojnotehnički Glasnik, 2012
If demand is known for the whole planning period (complete information), then this type of demand or a supply system is deterministic. In the simplest cases, the demand per time unit is constant.
Ivan S. Milojević, Rade V. Guberinić
doaj   +1 more source

Demand-side management strategies and the residential sector: Lessons from international experience

open access: yes, 2010
This paper explores demand side management (DSM) strategies, including both demand response and energy efficiency policies. The aim is to uncover what features might strengthen DSM effectiveness. We first look at key features of residential energy demand
Pollitt, Michael G   +7 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Route Planning Based On Urban Mobility Management

open access: yesHungarian Journal of Industry and Chemistry, 2016
Mobility management centres play a significant role in urban transport, taking into account several factors that have an effect on the flow of vehicles. In the present paper a mobility management centre equipped with necessary information and information
Mátrai Tamás   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Multi-Dimensional Assessment for Residential Lighting Demand Side Management: A Proposed Framework [PDF]

open access: yes, 2013
Effective Demand Side Management (DSM) practices require adequate assessment in which several important factors are taken into consideration. Criteria to measure DSM potential and set DSM targets are substantial to be well predefined.
Hosea, Emmy   +2 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Water demand management, poverty and equity

open access: yes, 2007
French version available in IDRC Digital Library: Gestion de la demande en eau, pauvreté et équitéThe paper outlines how questions of Water Demand Management (WDM), poverty and equity might be approached in a research framework, drawing on existing ...
Tyler, Stephen   +1 more
core  

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