Results 111 to 120 of about 1,206,124 (263)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessing the Demand Side Management Potential and the Energy Flexibility of Heat Pumps in Buildings

Energies, 2018
The energy demand in buildings represents a considerable share of the overall energy use. Given the significance and acknowledged flexibility of thermostatically controlled loads, they represent an interesting option for the implementation of demand side
Alessia Arteconi, Fabio Polonara
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Day-ahead and Day-in Decision Model Considering the Uncertainty of Multiple Kinds of Demand Response

Energies, 2019
The uncertainty of demand response (DR) will affect the economics of power grid dispatch due to the randomness of participating users’ intentions.
Siqing Sheng, Qing Gu
doaj   +1 more source

A Minimal Incentive-based Demand Response Program With Self Reported Baseline Mechanism

, 2019
In this paper, we propose a novel incentive based Demand Response (DR) program with a self reported baseline mechanism. The System Operator (SO) managing the DR program recruits consumers or aggregators of DR resources.
Baeyens, Enrique, Chakraborty, Pratyush, Khargonekar, Pramod P., Muthirayan, Deepan, Poolla, Kameshwar   +4 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Model for Multi-Energy Demand Response with Its Application in Optimal TOU Price

Energies, 2019
With the generalization of the integrated energy system (IES) on the demand side, multi-energy users may participate in a demand response (DR) program based on their flexible consumption of energy.
Nan Zhao, Beibei Wang, Mingshen Wang
doaj   +1 more source

Optimal Ensemble Control of Loads in Distribution Grids with Network Constraints

, 2018
Flexible loads, e.g. thermostatically controlled loads (TCLs), are technically feasible to participate in demand response (DR) programs. On the other hand, there is a number of challenges that need to be resolved before it can be implemented in practice ...
Chertkov, Michael, Deka, Deepjyoti, Dvorkin, Yury   +2 more
core   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Reviewing Demand Response for Energy Management with Consideration of Renewable Energy Sources and Electric Vehicles

World Electric Vehicle Journal
This review paper critically examines the role of demand response (DR) in energy management, considering the increasing integration of renewable energy sources (RESs) and the rise in electric vehicle (EV) adoption.
Benjamin Chatuanramtharnghaka, Subhasish Deb, Ksh Robert Singh, Taha Selim Ustun, Akhtar Kalam   +4 more
doaj   +1 more source