Results 111 to 120 of about 1,525,022 (327)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Bayesian Game-Theoretic Bidding Optimization for Aggregators Considering the Breach of Demand Response Resource

Applied Sciences, 2019
Demand response (DR) aggregator controlling and aggregating flexible resource of residential users to participate in DR market will contribute the performance of DR project.
Xiaofeng Liu, Bingtuan Gao, Yuanmei Li
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multi-Objective Demand Response Model Considering the Probabilistic Characteristic of Price Elastic Load

Energies, 2016
Demand response (DR) programs provide an effective approach for dealing with the challenge of wind power output fluctuations. Given that uncertain DR, such as price elastic load (PEL), plays an important role, the uncertainty of demand response behavior ...
Shengchun Yang, Dan Zeng, Hongfa Ding, Jianguo Yao, Ke Wang, Yaping Li   +5 more
doaj   +1 more source

Mechanism Design for Demand Response Programs [PDF]

, 2019
Demand Response (DR) programs serve to reduce the consumption of electricity at times when the supply is scarce and expensive. The utility informs the aggregator of an anticipated DR event. The aggregator calls on a subset of its pool of recruited agents
Kalathil, Dileep, Muthirayan, Deepan, Poolla, Kameshwar, Varaiya, Pravin   +3 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A Demand Side Adjustment Capacity Sharing Model Based on Cooperative Game

Zhongguo dianli
Under the background of demand response (DR) program, if load aggregators (LAs) are allowed to share the demand side adjustment capability, specifically, those with higher unit adjustment cost can purchase the adjustment services from those with lower ...
Jie ZHANG, Yufei HUA, Chen WANG
doaj   +1 more source

Flexibility Potential of Space Heating Demand Response in Buildings for District Heating Systems

Energies, 2019
Using an integrated demand-supply optimization model, this work investigates the potential for flexible space heating demand, i.e., demand response (DR), in buildings, as well as its effects on the heating demand and the operation of a district heating ...
Dmytro Romanchenko, Emil Nyholm, Mikael Odenberger, Filip Johnsson   +3 more
doaj   +1 more source

Virtual Power Player Using Demand Response to Deal with Unexpected Low Wind Power Generation [PDF]

, 2013
Demand response is assumed as an essential resource to fully achieve the smart grids operating benefits, namely in the context of competitive markets and of the increasing use of renewable-based energy sources.
Faria, Pedro, Vale, Zita
core