Results 121 to 130 of about 1,525,022 (327)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Applied Sciences, 2017 The uncertainty of wind power results in wind power forecasting errors (WPFE) which lead to difficulties in formulating dispatching strategies to maintain the power balance.
Jia Ning, Yi Tang, Bingtuan Gao
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Demand‐side price‐responsive flexibility and baseline estimation through end‐to‐end learning
IET Renewable Power GenerationTime‐varying electricity tariffs provide consumers the flexibility to adjust their consumption patterns in response to price variations to reduce the cost of electricity while at the same time contributing to grid operation.
Yuanyuan Shi, Bolun Xu
doaj +1 more source
Load Balancing with Energy Storage Systems Based on Co-Simulation of Multiple Smart Buildings and Distribution Networks [PDF]
, 2017 In this paper, we present a co-simulation framework that combines two main simulation tools, one that provides detailed multiple building energy simulation ability with Energy-Plus being the core engine, and the other one that is a distribution level ...
Ababei, Cristinel +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Assessing the Demand Side Management Potential and the Energy Flexibility of Heat Pumps in Buildings
Energies, 2018 The energy demand in buildings represents a considerable share of the overall energy use. Given the significance and acknowledged flexibility of thermostatically controlled loads, they represent an interesting option for the implementation of demand side
Alessia Arteconi, Fabio Polonara
doaj +1 more source
Analysing long-term interactions between demand response and different electricity markets using a stochastic market equilibrium model. ESRI WP585, February 2018 [PDF]
, 2018 Power systems based on renewable energy sources (RES) are characterised by increasingly distributed, volatile and uncertain supply leading to growing requirements for flexibility.
Bertsch, Valentin +3 more
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