Results 141 to 150 of about 39,009 (301)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Serve All or Selectively Accept? A Triple Bottom Line Assessment of Demand-Responsive Transport Service Policies

Findings
Demand-responsive transport (DRT) systems struggle to strike a balance between universal accessibility and efficient, equitable service delivery. This study utilises MATSim to evaluate two distinct DRT policies in Greater Melbourne: a serve-all policy ...
Sapan Tiwari
doaj   +1 more source

Improving mobility: Evaluating demand responsive transport (DRT) services for retirement communities in Santa Clara County, California

Transportation Research Interdisciplinary Perspectives
We address alternatives in local transportation service offerings to members of retirement communities. A continuing policy dialogue on serving the transportation needs of our retirement-aged citizens has directed attention to demand-responsive services.
Steven D. Silver
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Integration of freight transportation in demand responsive transport systems

, 2020
Demand-Responsive Transport (DRT) describes public transport modes, which do not run on a fixed schedule but the customers can order their trip including time windows, origin and destinations themselves. Especially for rural areas with lower demand for passengers, DRT systems seem to be suitable concepts.
openaire   +1 more source

Value of Reliability for the Waiting Stage, In-vehicle Stage and Transfer Stage of Demand Responsive Transport (DRT) Services

, 2018
On-demand modes are playing an ever-increasing role in urban transportation. Inparticular, Demand Responsive Transit (DRT) (shared on-demand modes such asshared ride-hailing and microtransit) can complement scheduled public transportthanks to their ...
van Oort, N. (author), Alonso González, M.J. (author), Hoogendoorn-Lanser, S. (author), Cats, O. (author), Hoogendoorn, S.P. (author)   +4 more
core  

INTERMODE: innovations in Demand Responsive Transport [PDF]

, 2004
INTERMODE: innovations in Demand Responsive ...
Graham Parkhurst (7179812), Marcus Enoch (1171632), Stephen Potter (4727505), Parkhurst, Graham, Potter, Stephen, Mark Smith (274792), Enoch, Marcus, Smith, Mark   +7 more
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source