Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Deep Reinforcement Learning Microgrid Optimization Strategy Considering Priority Flexible Demand Side. [PDF]
Sensors (Basel), 2022 Sang J, Sun H, Kou L.
europepmc +1 more source
Who are the Self-employed? A New Approach [PDF]
Whilst the individual supply-side characteristics of the self-employed are well documented, the literature has largely neglected (or mis-specified) demand-side aspects.
Brown, Sarah +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Barriers to effective hypertension management in rural Bihar, India: A cross-sectional, linked supply- and demand-side study. [PDF]
PLOS Glob Public Health, 2022 Peters MA +6 more
europepmc +1 more source
A cost-effectiveness analysis of demand- and supply-side education interventions [PDF]
This paper is concerned with the issue of the most cost-effective way of improving access to education for poor households in developing countries. We consider two alternatives: (1) extensive expansion of the school system (i.e., bringing education to ...
Coady, David P., Parker, Susan W.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Challenges in implementing preventive treatment for latent tuberculosis infection: a narrative review from provider and demand-side perspectives. [PDF]
Front Public HealthLing Y +10 more
europepmc +1 more source
Demand-side Interventions to Control Moral Hazard in Health Systems, Beneficial or Detrimental: A Systematic Review Study. [PDF]
Med J Islam Repub Iran, 2022 Koohi Rostamkalaee Z +2 more
europepmc +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source