Results 171 to 180 of about 28,647 (250)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Maternal Plasma and Breast Milk & Infant Cord Blood and Plasma: A Model‐Based Analysis of Mother–Infant Pairs for Tuberculosis Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
IMPAACT 2001 (NCT02651259) evaluated the safety and pharmacokinetics (PK) of once‐weekly isoniazid and rifapentine in pregnant and postpartum women for tuberculosis prevention. Rifapentine (RPT) and desacetyl rifapentine (desRPT) PK data were collected in maternal plasma, breast milk, infant cord blood, and infant plasma.
Priya Jayachandran, Jyoti S. Mathad, Nan Zhang, Paula Britto, Lubbe Wiesner, Grace Montepiedra, Jennifer Norman, Ellen Townley, Sarah Bradford, Sandesh Patil, Stephanie Popson, Tsungai Chipato, Vanessa Rouzier, Deborah Langat, Amphan Chalermchockcharoentkit, Amita Gupta, Kelly E. Dooley, Radojka Savic, on behalf of the IMPAACT 2001 Study Team   +18 more
wiley   +1 more source

A rock brittleness index based on the postpeak energy release rate and damage surface characteristics for brittle hard rock

Deep Underground Science and Engineering, EarlyView.
This study examines energy evolution in rock rupture via triaxial direct shear tests, exploring the impact of confining pressure and temperature on fracture surface randomness. A novel energy‐based brittleness index is proposed, validated experimentally, and compared with existing methods for reliability and accuracy.
Biao Wang, Zaobao Liu, Jing Xue, Bo Lu, Wei Zeng, Dengke Zhang   +5 more
wiley   +1 more source

Shock wave propagation characteristics of aluminum‐containing explosive in corrugated steel‐lined tunnel

Deep Underground Science and Engineering, EarlyView.
Aluminum‐enhanced afterburning renders AE explosives more hazardous than conventional ones. Corrugated steel linings reduce far‐field AE blast overpressure by ~50% through wave reflection and dissipation. The developed model accurately predicts peak pressure (<10% error) and arrival time (<3% error), supporting protective design.
Zhen Wang, Jiayu Peng, Hujun Li, Yuguo Ji, Shuobiao Li, Guokai Zhang   +5 more
wiley   +1 more source

A hierarchical adaptive strategy for selecting rheological models in intelligent backfill mining pipeline transportation systems

Deep Underground Science and Engineering, EarlyView.
This graphical abstract presents a hierarchical adaptive strategy for selecting rheological models in intelligent backfill pipeline transportation. Temperature, fly ash content, and water‐cement ratio jointly influence slurry rheological nonlinearity, which is quantified using the Model Fidelity Gain (ΔR2).
Defeng Wang, Xintao Song, Aixiang Wu, Yong Wang   +3 more
wiley   +1 more source

Dental development in the tropical gar (Atractosteus tropicus) and the evolution of vertebrate dentitions

Developmental Dynamics, EarlyView.
Abstract Background Dentitions have diversified enormously during vertebrate evolution, involving reductions, modifications, or allocations to prey seizing and processing regions. A combination of ancient and novel features related to dental and oropharyngeal apparatuses is found in extant lineages of non‐teleost fishes, such as the gars.
Anna Pospisilova, Jan Stundl, Lenin Arias‐Rodriguez, Robert Cerny, Vladimír Soukup   +4 more
wiley   +1 more source

Orthodentine‐osteodentine and osteocytic‐anosteocytic transition inferred from Silurian stem chondrichthyan dermal jawbones with ever‐white teeth overgrown by brown denticles

Developmental Dynamics, EarlyView.
Abstract Background The dentigerous jawbones of a 423‐million‐year‐old stem chondrichthyan (ischnacanthid acanthodian) carry a characteristic combination of multi‐row non‐shedding white teeth with brownish overgrowing denticles. The color distinction makes it a good model for observing the interaction between two odontode lineages, but the nature of ...
Jia‐Cih Kang, Henning Blom, Tiiu Märss, Donglei Chen   +3 more
wiley   +1 more source

Spatially heterogenous range dynamics since the Last Glacial Maximum underpin the modern bimodal latitudinal diversity gradient in planktonic foraminifera

Ecography, EarlyView.
The modern latitudinal diversity gradient (LDG) of planktonic foraminifera is bimodal, with a distinct depression near the equator surrounded by mid‐latitude diversity peaks. This pattern emerged after the Last Glacial Maximum (LGM; 19–23 ka), but it remains unclear how species' spatial dynamics contributed to its formation.
Tasnuva Ming Khan, Marina C. Rillo, Lukas Jonkers, Isaiah E. Smith, Ádám T. Kocsis, Wolfgang Kiessling   +5 more
wiley   +1 more source

Direct cortical stimulation–evoked symptoms in the human temporal pole: A systematic review

Epileptic Disorders, EarlyView.
Abstract The temporal pole represents a key node within temporolimbic networks and may contribute to seizure generation in temporal lobe epilepsy. Direct cortical stimulation (DCS), performed during intracranial presurgical evaluation, is a valuable method for delineating the seizure onset zone by reproducing electro‐clinical features of a patient's ...
Yulia Novitskaya, Andreas Schulze‐Bonhage   +1 more
wiley   +1 more source

Fire Spread Characteristics of Cavities in Modular Constructions and Ventilated Facades

Fire and Materials, EarlyView.
ABSTRACT Modular buildings have gained popularity as a sustainable building solution. However, the uncertainty of fire spread through vertical cavity spaces in such buildings has become a concern. Therefore, this study aims to fill the gap in fire behaviour within vertical cavity spaces.
Rajeendra Godakandage, Pasindu Weerasinghe, Satheeskumar Navaratnam, Kumari Gamage, Kate (Quynh Thuy) Nguyen   +4 more
wiley   +1 more source