Results 301 to 310 of about 1,302,226 (351)

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Predictors of Anorexia Nervosa and Obsessive‐Compulsive Disorder Comorbidity and Order of Diagnosis in a Danish National Cohort

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) and obsessive‐compulsive disorder (OCD) are highly comorbid; however, limited research has examined etiological pathways specific to individuals with AN developing OCD or individuals with OCD developing AN. This exploratory study aimed to identify factors influencing AN‐OCD comorbidity with a focus on the order ...
Lisa Yujia Zhu, Janne Tidselbak Larsen, Judith Becker Nissen, James J. Crowley, Manuel Mattheisen, Cynthia M. Bulik, Liselotte Vogdrup Petersen, Zeynep Yilmaz   +7 more
wiley   +1 more source

"I know you didn't want to stay": Emergency Department Conversations about Disposition for People Living with Dementia. [PDF]

Gerontologist
Seidenfeld J, Tucker M, Harris-Gersten M, Fix GM, Sperber NR, Hastings SN.   +5 more
europepmc   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes. [PDF]

Genome Med
Chia SY, Li M, Li Z, Tu H, Lee JWL, Qiu L, Ling J, Reynolds R, Albani S, Tan EK, Ng ASL, Chen J, Zeng L.   +12 more
europepmc   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Bridging gaps in dementia care across southeastern Europe: Regional challenges, cross-border innovation, and implementation barriers. [PDF]

J Public Health Res
Kurz C, Alimehmeti I, Boban M, Kostic S, Sinanovic O, Kučuk O, Mehrabian S, Traykov L, Mimica N, Novotni G, Pfaeffel L, Dogan V, Diehl-Schmid J, Alexopoulos P, Grünhaus C, Pirtošek Z, Kurz A.   +16 more
europepmc   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study. [PDF]

BMJ Neurol Open
Gribsholt SB, Horváth-Puhó E, Elser H, Laugesen K, Skajaa N, Fuglsang CH, Henderson V, Sørensen HT.   +7 more
europepmc   +1 more source

Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization

ESC Heart Failure, Volume 12, Issue 2, Page 1227-1236, April 2025.
Comparative performance of 7 risk prediction indices in patients hospitalized for heart failure. In this cohort of 1206 patients, the LENT index offered the greatest discrimination, calibration, and overall accuracy in predicting 30‐day composite all‐cause mortality or readmission following hospitalization for heart failure.
Tauben Averbuch, Ali Zafari, Shofiqul Islam, Shun Fu Lee, Rajiv Sankaranarayanan, Stephen J Greene, Mamas A Mamas, Ambarish Pandey, Harriette GC Van Spall   +8 more
wiley   +1 more source