Results 81 to 90 of about 940,684 (303)

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain

Acta Neuropathologica Communications
Background Accumulated levels of mutant huntingtin protein (mHTT) and its fragments are considered contributors to the pathogenesis of Huntington’s disease (HD).
Martin J. Berg, Veeranna, Corrinne M. Rosa, Asok Kumar, Panaiyur S. Mohan, Philip Stavrides, Sandipkumar Darji, Deanna M. Marchionini, Dun-Sheng Yang, Ralph A. Nixon   +9 more
doaj   +1 more source

A collective case study of the features of impactful dementia training for care home staff

BMC Geriatrics, 2019
Background Up to 80% of care home residents have dementia. Ensuring this workforce is appropriately trained is of international concern. Research indicates variable impact of training on a range of resident and staff outcomes. Little is still known about
Claire A. Surr, Cara Sass, Michelle Drury, Natasha Burnley, Alison Dennison, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Providing Basic Needs and Encouragement as Strategies in Managing Aggression in Dementia Clients [PDF]

, 2013
Purpose: The experiences of caregivers in managing dementia clients with aggressive behaviour have been an issue in nursing homes. This study utilized the fact that there is no significant strategy for managing aggression effectively.
Cross, W. (Wendy), Lestari, R. (Retno)
core  

Developing Dementia-Friendly Tourism Destinations: An Exploratory Analysis [PDF]

, 2014
Dementia is emerging as a global issue. Increases in life expectancy create an older population structure with accompanying health needs but also high lifestyle expectations.
Alzheimer’s Society, Anthea Innes, Argyle M., Bryman A., Cassolato C., Clare Cutler, Clift S., Hall C. M., House of Commons Commission and Local Government and Communities, Houston A., Innes A., Innes A., Johnson A., Kazeminia A., Kleiber D., Kuzamanov C., Luengo-Fernandez R., Mapes N., McCabe S., Morrison A., Page S. J., Paillard-Borg S., Prime Ministers Dementia Challenge, Ritchie J. B., Scott D., Smith D. M., Stationery Office, Stephen J. Page, Tedrick T., UNWTO, VisitEngland, Wilkes J., Woods S.   +32 more
core   +1 more source

White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration

NeuroImage: Clinical, 2015
Impairments of social cognition are often leading features in frontotemporal lobar degeneration (FTLD) and likely to reflect large-scale brain network disintegration. However, the neuroanatomical basis of impaired social cognition in FTLD and the role of
Laura E. Downey, Colin J. Mahoney, Aisling H. Buckley, Hannah L. Golden, Susie M. Henley, Nicole Schmitz, Jonathan M. Schott, Ivor J. Simpson, Sebastien Ourselin, Nick C. Fox, Sebastian J. Crutch, Jason D. Warren   +11 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

SenseCam intervention based on cognitive ctimulation therapy framework for early-stage dementia. [PDF]

, 2011
Estimates suggest that Ireland will have 50,000 people with dementia by 2016 and over 100,000 by 2036. Combined with European total costs estimated in 2005 at €130 billion.
Irving, Kate, Piasek, Paulina, Smeaton, Alan F.   +2 more
core  

Role of Artificial Intelligence (AI) art in care of ageing society: focus on dementia [PDF]

, 2019
open access articleBackground: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and ...
Harwood, Tracy, Maltby, John, Mukaetova-Ladinska, Elizabeta   +2 more
core   +1 more source

The brain basis of musicophilia: evidence from frontotemporal lobar degeneration

Frontiers in Psychology, 2013
Musicophilia, or abnormal craving for music, is a poorly understood phenomenon that has been associated in particular with focal degeneration of the temporal lobes.
Phillip David Fletcher, Laura eDowney, Pirada eWitoonpanich, Jason eWarren   +3 more
doaj   +1 more source