Results 81 to 90 of about 1,330,157 (395)

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

Nature Communications
DNA-protein interactions have traditionally been profiled via chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq). Cleavage Under Targets & Tagmentation (CUT&Tag) is a rapidly expanding technique that enables the profiling of ...
Leyla Abbasova, Paulina Urbanaviciute, Di Hu, Joy N. Ismail, Brian M. Schilder, Alexi Nott, Nathan G. Skene, Sarah J. Marzi   +7 more
doaj   +1 more source

The barriers and facilitators to implementing dementia education and training in health and social care services: a mixed-methods study

BMC Health Services Research, 2020
Background The health and social care workforce requires access to appropriate education and training to provide quality care for people with dementia. Success of a training programme depends on staff ability to put their learning into practice through ...
Claire A. Surr, Sahdia Parveen, Sarah J. Smith, Michelle Drury, Cara Sass, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Polygenic risk and pleiotropy in neurodegenerative diseases

Neurobiology of Disease, 2020
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS)
Eftychia Bellou, Joshua Stevenson-Hoare, Valentina Escott-Price   +2 more
doaj   +1 more source

Senile Dementia and Presenile Dementia

The Tohoku Journal of Experimental Medicine, 1990
Neurotransmitters including acetylcholine, dopamine, norepinephrine, serotonin, GABA and vasopressin were examined in control subjects and patients with Alzheimer-type dementia, involving presenile and senile dementia. Neurotransmitters exhibited various mode of changes with aging.
openaire   +3 more sources

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

A collective case study of the features of impactful dementia training for care home staff

BMC Geriatrics, 2019
Background Up to 80% of care home residents have dementia. Ensuring this workforce is appropriately trained is of international concern. Research indicates variable impact of training on a range of resident and staff outcomes. Little is still known about
Claire A. Surr, Cara Sass, Michelle Drury, Natasha Burnley, Alison Dennison, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Medicines management issues in dementia and coping strategies used by people living with dementia and family carers: a systematic review [PDF]

, 2018
Objectives: Medicines play a key role in the lives of people with dementia, primarily to manage symptoms. Managing medicines is complex for people with dementia and their family carers and can result in multiple problems leading to harm. We conducted a
Lim, Rosemary H., Sharmeen, Taniya
core   +1 more source

Plasma p‐tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Plasma p‐tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p‐tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).
Giulia Giacomucci, Assunta Ingannato, Chiara Crucitti, Silvia Bagnoli, Elisa Marcantelli, Sonia Padiglioni, Valentina Moschini, Carmen Morinelli, Laura Falsini, Sandro Sorbi, Valentina Berti, Benedetta Nacmias, Valentina Bessi   +12 more
wiley   +1 more source

Risk factors for dementia in the ninth decade of life and beyond: a study of the Lothian birth cohort 1921

BMC Psychiatry, 2017
Background With increasing numbers of people surviving beyond eighty years, this section of the population demands attention to reduce the impact of dementia.
Ruth A. Sibbett, Tom C. Russ, Ian J. Deary, John M. Starr   +3 more
doaj   +1 more source