Results 31 to 40 of about 46,885 (268)

The Pain of Modern Life: The Misery of Modern Existence

open access: yesResearch on Ageing and Social Policy
Social isolation and loneliness are posing more problems than ever. There are concerns that the long-term effects of loneliness will be felt when the COVID-19 outbreak reaches its third year.
Meltem Ince Yenilmez   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Adaption and validation of the childbirth experience questionnaire (CEQ-SK) in Slovakia

open access: yesEuropean Journal of Midwifery, 2023
Introduction Using validated and reliable instruments to examine women’s birth experiences is important to ensure respectful care. There is a lack of validated instruments for evaluating childbirth care in the Slovak context.
Lena Henriksen   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Harmonizing the fundamental principles of economy and moral philosophy

open access: yesFocus on Research in Contemporary Economics, 2020
In its simplest form, morality refers to the value judgments that we define as "good" or "right" in human relations. Here, questions arise such as "what is understood from good? what is the criteria?, and what is good for whom?".
Cemil Ertuğrul, Ebru Unat
doaj  

A Critical Review on the Complex Interplay between Social Determinants of Health and Maternal and Infant Mortality

open access: yesChildren, 2022
Background: U.S. maternal and infant mortality rates constitute an important public health problem, because these rates surpass those in developed countries and are characterized by stark disparities for racial/ethnic minorities, rural residents, and ...
Rada K. Dagher, Deborah E. Linares
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Parental Perspectives on Mixed-Age Education in Early Childhood

open access: yesVan Yüzüncü Yıl Üniversitesi Eğitim Fakültesi Dergisi
The family plays a crucial role in the development of individuals, particularly in the acquisition of emotional and social skills during early childhood.
Gaye Cizdan, Aysun Turupcu
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

The Mysterious Travel of Drugs from Nature to Pharmacy

open access: yesForbes Tıp Dergisi
For thousands of years, people have used various substances found in nature to relieve symptoms and even cure diseases. Drugs are medicinal products obtained from natural sources such as plants, animals, and microorganisms or synthesized in the ...
Gülden DİNİZ   +5 more
doaj   +1 more source

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