Results 31 to 40 of about 330,051 (318)

Subverting Democracy in the Name of Democracy

open access: yesDemocratization
Attempts to subvert democracy are often justified, paradoxically, as an effort to save orimprove democracy. Yet, little is known about the effectiveness of these justifications. Here,we conduct two original vignette experiments, where US American and Polish respondentsare introduced to a proposal of executive aggrandizement, usurping control over ...
Alexander Bor, Honorata Mazepus
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Mindfulness, Democracy, and Education

open access: yes, 2015
In this article, we explain how mindfulness can enhance a democratic way of being, connecting practices of awareness, reflection, dialog, and action to democratic citizenship and social arrangements.
LaPrad, James G, Hyde, Andrea Marie
core   +1 more source

The Pain of Modern Life: The Misery of Modern Existence

open access: yesResearch on Ageing and Social Policy
Social isolation and loneliness are posing more problems than ever. There are concerns that the long-term effects of loneliness will be felt when the COVID-19 outbreak reaches its third year.
Meltem Ince Yenilmez   +1 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Examination of the New Tech Model as a Holistic Democracy

open access: yes, 2017
Using the Degrees of Democracy Framework (Woods & Woods, 2012), we examined eight New Tech (NT) high schools to determine the extent to which they demonstrated characteristics of holistic democracy.
Mosier, Gina   +1 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Public Schooling for Democracy. A Book Review of \u3cem\u3ePublic Education: Defending a Cornerstone of American Democracy\u3c/em\u3e [PDF]

open access: yes
This essay is a book review of Public Education: Defending a Cornerstone of American ...
Reid, Ellis E, V
core   +1 more source

Harmonizing the fundamental principles of economy and moral philosophy

open access: yesFocus on Research in Contemporary Economics, 2020
In its simplest form, morality refers to the value judgments that we define as "good" or "right" in human relations. Here, questions arise such as "what is understood from good? what is the criteria?, and what is good for whom?".
Cemil Ertuğrul, Ebru Unat
doaj  

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