Results 121 to 130 of about 6,164 (219)

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

open access: yesAdvanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li   +9 more
wiley   +1 more source

Excitation‐Selective Hydrochromic Upconversion in Zero‐Dimensional Metal Halides

open access: yesAdvanced Science, EarlyView.
Excitation wavelength dictates whether moisture speaks. In zero‐dimensional metal halides, the same humidity leaves the upconversion emission unchanged under 980 nm excitation yet triggers a distinct green‐to‐red shift under 1550 nm. This excitation‐selective hydrochromism, governed by the absorption at each wavelength, enables stimulus‐dependent ...
Joo Hyeong Han   +6 more
wiley   +1 more source

Synergistic Mechano‐Fluidic Self‐Fusion of Poly(Vinyl Alcohol)‐Modified Liquid‐Metal Particles for Post‐Treatment‐Free Soft Electronics

open access: yesAdvanced Science, EarlyView.
Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook   +13 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

open access: yesAdvanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

open access: yesAdvanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao   +11 more
wiley   +1 more source

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