ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang +13 more
wiley +1 more source
Population meeting surveillance-based thresholds for metabolic and bariatric surgery evaluation under the 1991 NIH and 2022 ASMBS/IFSO criteria across 37 settings: STEPS analysis and projections to 2030. [PDF]
Vera-Ponce VJ.
europepmc +1 more source
Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang +7 more
wiley +1 more source
Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella +5 more
wiley +1 more source
The shifting burden of tracheal, bronchus and lung cancer in ageing Asia: structural drivers and projections to 2050. [PDF]
Zhu L +5 more
europepmc +1 more source
Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello +10 more
wiley +1 more source
Identifying Key Determinants of Fertility Among Women in Bangladesh Using Machine Learning Tools: Evidence From the BDHS 2022. [PDF]
Sumi SA, Umar MT, Haque A, Hossain MM.
europepmc +1 more source
Predictive modeling of clonal hematopoiesis across diverse cohorts. [PDF]
Batchi-Bouyou AL +13 more
europepmc +1 more source

