Results 51 to 60 of about 2,564,411 (316)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Reassessing socioeconomic inequalities in mortality via distributional similarities

Population Health Metrics
Commonly used measures of socioeconomic inequalities in mortality, such as the slope and the relative index of inequality, are based on summary measures of the group-specific age-at-death distributions (e.g. standardized mortality rate or life expectancy)
Ana C. Gómez-Ugarte, Ugofilippo Basellini, Carlo G. Camarda, Fanny Janssen, Emilio Zagheni   +4 more
doaj   +1 more source

Geospatial examination of tap water pollution in residential areas of the Al-Abbasiya neighborhood, Najaf, Iraq [PDF]

E3S Web of Conferences
The present study measured radon (222Rn) levels in the drinking water obtained from thirty houses distributed within Al-Abbasiya District, Najaf City, Iraq to estimate public health risk and adherence to safety standards set by international ...
Ridha Raya Fadhil, Abbas Shurooq Lafta, Matar Lina Majeed, Yousif Saja Nafea, Alhiti Laith S.   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Socio-economic determinants of divorce in Lithuania: Evidence from register-based census-linked data

Demographic Research, 2015
Background: Most existing evidence on the socio-economic predictors of divorce in developed countries comes from the USA and from Western and Northern Europe. This study contributes to the scarce literature about socio-economic determinants of divorce in
Ausra Maslauskaite, Aiva Jasilioniene, Domantas Jasilionis, Vladislava Stankuniene, Vladimir M. Shkolnikov   +4 more
doaj   +1 more source

Generations and Gender Survey (GGS): Towards a Better Understanding of Relationships and Processes in the Life Course

, 2007
The Generations and Gender Survey (GGS) is one of the two pillars of the Generations and Gender Programme designed to improve understanding of demographic and social development and of the factors that influence these developments. This article describes
Pailhé, Ariane, Andres Vikat, Spéder, Zsolt, Fokkema, Tineke, Jan M. Hoem, Hoem, Jan M., Francesco C. Billari, Alphonse MacDonald, Zsolt Spéder, Anne Solaz, Tineke Fokkema, Gijs Beets, Pailhé, A., Francesco Billari, Aline Desesquelles, Antonella Pinnelli, Spéder, Z., Pinnelli, A., Vikat, Andres, Christoph Bühler, Zsolt Spéder, Neyer, G., Ariane Pailhé, Fokkema, C.M., Gerda Neyer, Ariane Pailhé, Christoph Bühler, Bühler, Christoph, Pinnelli, Antonella, Désesquelles, A., Solaz, A., Beets, G.C.N., Billari, Francesco, MacDonald, A., Hoem, J., Neyer, Gerda, Aline Désesquelles, MacDonald, Alphonse, Bühler, C., Hoem, Jan Michael, Billari, F., Vikat, A., Beets, Gijs, Desesquelles, Aline, Solaz, Anne   +44 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The German Generations and Gender Survey:
Some Critical Reflections on the Validity of Fertility Histories

Comparative Population Studies, 2013
This paper validates the fertility histories of the German Generations and Gender Survey (GGS). Focusing on the cohorts 1930-69 of West German women, the total number of children, the parity distribution and the parity progression ratios are compared to ...
Michaela Kreyenfeld, Anne Hornung, Karolin Kubisch   +2 more
doaj  

Income sources and intergenerational transfers in different regimes: The case of East Germany's transformation

Demographic Research, 2015
Background: Intergenerational transfers are a fundamental feature of the economic life cycle. In western welfare states, private transfers typically flow from members of the older generations to their children and grandchildren, especially when in need ...
Fanny Annemarie Kluge, Tobias Vogt
doaj   +1 more source