Results 251 to 260 of about 5,326,112 (324)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Microclimate drives demographic compensation in a narrow endemic tropical species. [PDF]

New Phytol
Zupo T, Escobar DF, Santos GS, Kamimura VA, Dias YN, de Assis RL, Caldeira CF, Watanabe MTC, Portela RCQ, Tavares V, Carvalho CDS.   +10 more
europepmc   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

The demographic transition influences variance in fitness and selection on height and BMI in rural Gambia.

Curr Biol, 2013
Courtiol A, Rickard IJ, Lummaa V, Prentice AM, Fulford AJ, Stearns SC.   +5 more
europepmc   +1 more source

Cause-specific mortality transition among women of reproductive age with special reference to maternal mortality: the Magu health and demographic surveillance system, Tanzania, 1995-2022. [PDF]

Glob Health Action
Marston M, Kagoye S, Materu J, Mangya C, Todd J, Urassa M, Boerma T.   +6 more
europepmc   +1 more source

A quasi-Experimental study to evaluate the effectiveness of a structured teaching program to reduce menopausal transition symptoms in urban perimenopausal women. [PDF]

J Family Med Prim Care
Nagavalli V, Sudha V, Sevvanthi K, Rachel J.   +3 more
europepmc   +1 more source

Altered EEG microstate associated with anxiety and somatization symptoms in major depressive disorder. [PDF]

Front Psychiatry
Shan Q, Wu G, Xiong Y, Guo Q, Hu H, Zhang F, Qian Z, Zhang T, Liu X.   +8 more
europepmc   +1 more source

PhaseGen: exact solutions for time-inhomogeneous multivariate coalescent distributions under diverse demographies. [PDF]

Genetics
Sendrowski J, Hobolth A.
europepmc   +1 more source

Long-Term Trends and Determinants of Tuberculosis Burden in China, 1990-2023: Insights from the Global Burden of Disease Study 2023. [PDF]

Pathogens
Wang Y, He G, Ng H, Niu C, Li R, Zhang F, Shi R, Dian X, Ma Q, Sun Z.   +9 more
europepmc   +1 more source