Results 61 to 70 of about 951,455 (268)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Unsupervised Modelling of E-Customers’ Profiles: Multiple Correspondence Analysis with Hierarchical Clustering of Principal Components and Machine Learning Classifiers

Mathematics
The rapid growth of e-commerce has transformed customer behaviors, demanding deeper insights into how demographic factors shape online user preferences. This study performed a threefold analysis to understand the impact of these changes.
Vijoleta Vrhovac, Marko Orošnjak, Kristina Ristić, Nemanja Sremčev, Mitar Jocanović, Jelena Spajić, Nebojša Brkljač   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ubuntu leadership and employee engagement in mining: The moderating role of safety culture

SA Journal of Human Resource Management
Orientation: This study explored the influence of Ubuntu leadership on employee engagement in South Africa’s mining industry, with a focus on the moderating role of safety culture. Research purpose: The purpose was to examine whether Ubuntu leadership
Mpho B. Nelwamondo, Gavin Price
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Dynamics Of Small Towns In France

European Countryside, 2016
This article is based on a renewed, unified functional definition of France’s urban hierarchy. Our ranking defines small towns exclusively in terms of their commercial and service functions, not according to size (population or jobs).
Jousseaume Valérie, Talandier Magali
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Workforce Diversity: A Spotlight on Employee Sustainability Excellence in India

Foundations of Management
This research paper explores a crucial yet often underestimated nexus: the relationship between workforce diversity and employee sustainability in the vibrant television media industry.
AISWARYA Balachandar, RAMASUNDARAM Gurusamy, SUDHA Paulin, POONDY Rajan   +3 more
doaj   +1 more source

Predictive Markers of Post-Stroke Cognitive Recovery and Depression in Ischemic Stroke Patients: A 6-Month Longitudinal Study

European Journal of Investigation in Health, Psychology and Education
The growing number of stroke survivors face physical, cognitive, and psychosocial impairments, making stroke a significant contributor to global disability. Various factors have been identified as key predictors of post-stroke outcomes.
Anna Tsiakiri, Spyridon Plakias, Pinelopi Vlotinou, Aikaterini Terzoudi, Aspasia Serdari, Dimitrios Tsiptsios, Georgia Karakitsiou, Evlampia Psatha, Sofia Kitmeridou, Efstratios Karavasilis, Nikolaos Aggelousis, Konstantinos Vadikolias, Foteini Christidi   +12 more
doaj   +1 more source