Results 131 to 140 of about 20,510 (219)

Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Heterogeneity is a critical factor in understanding inter‐individual brain and behavioral variability in autism spectrum disorder (ASD). Since individuals with ASD exhibit atypical communication and social interaction skills closely linked to brain lateralization, this study investigated ASD heterogeneity using an asymmetry index that captures
Chae Yeon Kim, Sunghun Kim, Bo‐yong Park   +2 more
wiley   +1 more source

Illicit drug supply, naloxone availability, and overdose mortality in the fentanyl era: a systematic review. [PDF]

Health Aff Sch
Khezri M, Holm J, Dahlen A, Johnson C, Agyabeng K, Lei F, Pagán JA, Healton C, Farhat T.   +8 more
europepmc   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Demography of lemmings in response to changing snow conditions in the High Arctic. [PDF]

Ecology
Poirier M, Gauthier G, Dominé F, Fauteux D.   +3 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Protocol for a multicentre survey of sexual and reproductive health and fertility among unmarried women living in China's megacities. [PDF]

BMJ Open
Yang F, Hu J, Liu H, Liu T, Wu D, Stewart T, Chen G.   +6 more
europepmc   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

The validity of Blue Zones demography: a response to critiques. [PDF]

Gerontologist
Austad SN, Pes GM.
europepmc   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Demographic Drivers of Population Decline in the Endangered Korean Fir (<i>Abies koreana</i>): Insights from a Bayesian Integral Projection Model. [PDF]

Plants (Basel)
Park JS, Lee J, Yun CW.
europepmc   +1 more source