Results 31 to 40 of about 20,510 (219)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

What are the causes of death of patients with tuberculosis? Multiple causes of death in a cohort of cases and a research proposal of presumed causes

International Journal of Population Data Science, 2017
Objetctive The objective of this study was to analyze the multiple causes of death in a cohort of patients with tuberculosis (TB) and to introduce an investigation proposal death for TB from a list of presumable causes.
Marli Rocha, Rejane Pinheiro, Gisele Oliveira, Fernanda Aguiar, Valéria Saraceni   +4 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Evaluation of advanced techniques for multi-party privacy-preserving record linkage on real-world health databases

International Journal of Population Data Science, 2017
Objective The linking of multiple (three or more) health databases is challenging because of the increasing sizes of databases, the number of parties among which they are to be linked, and privacy concerns related to the use of personal data such as ...
Thilina Ranbaduge, Dinusha Vatsalan, Sean Randall, Peter Christen   +3 more
doaj   +1 more source

Exploring how to improve the involvement of Polish and South Asian communities around big data research. A qualitative study using COM-B model

International Journal of Population Data Science, 2023
Introduction Involving public contributors helps researchers to ensure that public views are taken into consideration when designing and planning research, so that it is person-centred and relevant to the public.
Piotr Teodorowski, Sarah E. Rodgers, Kate Fleming, Naheed Tahir, Saiqa Ahmed, Lucy Frith   +5 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

An Integrated Genomics and Clinical Resource for Data-Driven Health Services Policy and Practice Decisionmaking

International Journal of Population Data Science, 2017
Objectives Biomedical understanding of cancer is evolving rapidly. Post-genomics cancer research is also being taken up in prevention, screening, treatment, and survivor programs to better identify and manage the risks and sequelae of cancer. In order to
Mary Mcbride, Samuel Aparicio, John Spinelli, Scott Tyldesley   +3 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

Ontario’s stroke report cards: Cross-continuum data linkage allows evaluation of system of care

International Journal of Population Data Science, 2018
Introduction Report cards or scorecards typically reflect one particular sector along the care continuum; however, stroke patients typically require acute care, inpatient rehabilitation and community care highlighting the need to link data sources to ...
Ruth Hall, Ferhana Khan, Jen Levi, Huiting Ma, Cally Martin, Cheryl Moher, Linda Kelloway, Elizabeth Linkewich, Mark Bayley   +8 more
doaj   +1 more source