Results 261 to 270 of about 76,100 (290)
Some of the next articles are maybe not open access.
Pathology of Demyelinating Diseases
Annual Review of Pathology: Mechanisms of Disease, 2012There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases. Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity ...
Claudia F. Lucchinetti +1 more
openaire +3 more sources
Demyelinating diseases in Asia
Current Opinion in Neurology, 2016The present review aims to discuss the recent advances in inflammatory demyelinating diseases of the central nervous system in Asia.Prevalence of multiple sclerosis (MS) in Asia is lower than that in Western countries, although it has been increasing recently.
Kazuo Fujihara, Hirofumi Ochi
openaire +3 more sources
Pediatric Demyelinating Diseases
Continuum, 2013In the past decade, the number of studies related to demyelinating diseases in children has exponentially increased. Demyelinating disease in children may be monophasic or chronic. Typical monophasic disorders in children are acute disseminated encephalomyelitis and clinically isolated syndromes, including optic neuritis and transverse myelitis ...
openaire +3 more sources
Demyelination in peroxisomal diseases
Journal of the Neurological Sciences, 2005Peroxisomal disorders that display neurologic involvement usually show a variety of abnormalities in white matter of the central nervous system (CNS). Adult Refsum’s disease primarily exhibits a hypertrophic (onion bulb) demyelinating neuropathy. The changes in CNS white matter vary greatly between these diseases, but basically can be divided into ...
openaire +3 more sources
The Biochemistry of Demyelination and Demyelinating Diseases
1972Wallerian degeneration was the first experimental model of demyelination devised and has been widely investigated both structurally and biochemically. After severing a peripheral nerve there is increasing loss of cerebrosides, sphingomyelin, cholesterol and phospholipids, that of the cephalins starting earlier and exceeding that of lecithin [1]. During
openaire +2 more sources
2001
Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
openaire +1 more source
Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
openaire +1 more source
Pathology and pathogenesis of demyelinating diseases
Current Opinion in Neurology, 1997Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system of putative autoimmune origin. In the present review the hypothesis that autoimmunity against multiple different brain antigens can lead to T-cell mediated brain inflammation and that multiple different immunological mechanisms may be responsible for the ...
Hans Lassmann, Maria K. Storch
openaire +3 more sources
Acute and Chronic Demyelinating Disease
Otolaryngologic Clinics of North America, 1987There are multiple entities subsumed under this title that have in common the primary destruction of central nervous system myelin with relative sparing of axons. The hereditary diseases are often referred to as dysmyelinating diseases in which there is a genetic defect in the formation or maintenance of myelin; they usually occur in children.
openaire +3 more sources
Demyelinating Disease: Evolution of a Paradigm
Neurochemical Research, 1999Multiple sclerosis was at one time viewed as a spiritual (God-given) disorder; only much later was it recognized as a scarring process. With advancing scientific knowledge, it was seen as a primarily demyelinating disease, later as thromboembolic in origin, and finally as inflammatory and destructive, probably an immunologic response to exogenous ...
openaire +3 more sources