Results 251 to 260 of about 6,801,890 (343)

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Parallel Morphological and Functional Development in the Xenopus Retinotectal System. [PDF]

Dev Neurobiol
Li VJ, Foubert D, Schohl A, Ruthazer ES.
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Tumor Microenvironment in Cancer Biology: A Comprehensive Review of Stromal, Immune, and Vascular Components Driving Malignancy. [PDF]

Cureus
T A S, Gupta S, Kiyawat P, Darshan Y, Sambhav K, Shamshadali SS.   +5 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Follicular Dendritic Cell Sarcoma Complicated With Preeclampsia and Fetal Growth Restriction in Pregnancy. [PDF]

Case Rep Med
Keven MC, Esendağlı G, Savaş M, Aydoğdu E, Sert A, Yeğen BD, Birge Ö, Bostancı H.   +7 more
europepmc   +1 more source

Connectivity indices can predict population persistence in river networks: insights from a metapopulation model. [PDF]

Landsc Ecol
Gharouni A, Pither R, Rayfield B, Cote D, Lutscher F.   +4 more
europepmc   +1 more source

Mast Cells Accumulate in the Stroma of Breast Adenocarcinoma and Secrete Pro-Inflammatory Cytokines and Tumor-Damaging Mediators: Could IL-37 and IL-38 Play an Anti-Tumor Role? [PDF]

Int J Mol Sci
Conti P, Gallenga CE, Annicchiarico C, Coppola A, Pellegrino R, Conti MJ, Mastrangelo F.   +6 more
europepmc   +1 more source

Intratumoral dendritic cell immunotherapy controls dissemination of metastasis-initiating cancer cells, even in patients with metastatic breast cancer. [PDF]

J Immunother Cancer
Soyano A, Lee MC, Han HS, Aldrich A, Soliman H, Olson-Mcpeek SK, Balsay-Patel CN, Aiello P, Farrell CM, Weinfurtner R, Burgos E, Czerniecki BJ, Ramamoorthi G.   +12 more
europepmc   +1 more source

A dendritic guidance receptor functions in both ligand dependent and independent modes. [PDF]

PLoS Genet
Reddy AR, Machera SJ, Cook ZT, Deng H, Nawrocka WI, Özkan E, Shen K.   +6 more
europepmc   +1 more source