Results 151 to 160 of about 178,253 (288)
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner +5 more
wiley +1 more source
Corrigendum: Drug repurposing approach against chikungunya virus: an in vitro and in silico study
Bhagyashri Kasabe +8 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
[Hemorrhagic dengue in primary dengue].
We described the clinical and humoral development of a 7-years old boy who had hemorrhagic dengue in the dengue epidemic taken place in Santiago de Cuba in 1997. During this stage, dengue was serologically confirmed in 77 patients under 15 years of age but only one case was considered to be hemorrhagic dengue in spite of the fact that the patient had ...
H, Palacios Serrano +2 more
openaire +1 more source
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun +6 more
wiley +1 more source
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
The Baboon as a Model to Study Human Health and Complex Disease
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley +1 more source
Acute acalculous cholecystitis in a teenager with hepatitis a virus infection: a case report
Luiz José de Souza +3 more
doaj +1 more source
Proactive Initiative to Establish a Dengue-Free Factory Assessment Framework in Dengue High-Risk Industrial Areas: A Narrative Review. [PDF]
Ritthison W +3 more
europepmc +1 more source

