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Dengue vaccines: progress and challenges

Current Opinion in Immunology, 2011
With several dengue vaccine candidates progressing through clinical trials, several options for controlling this disease appear feasible. This would represent a major achievement and reflect decades of research and development activities. The challenges associated with the limited understanding of protective responses and those factors which determine ...
Beth-Ann G, Coller, David E, Clements
openaire   +2 more sources

Dengue Virus Vaccine Development

2014
Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range from asymptomatic to a self-limited febrile illness, dengue fever (DF), to the life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Lauren E, Yauch, Sujan, Shresta
openaire   +2 more sources

Vaccination for Dengue Prevention

JAMA, 2022
Laura E, Adams   +2 more
openaire   +2 more sources

Dengue vaccine.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006
Dengue is an expanding health problem. About two-fifths of the world population are at risk for acquiring dengue with 50-100 million cases of acute febrile illness yearly including about 500,000 cases of DHF/DSS. No antiviral drugs active against the flavivirus exist. Attempts to control mosquito vector has been largely unsuccessful.
Sriluck, Simasathien   +1 more
openaire   +1 more source

DENGUE VACCINES.

The Southeast Asian journal of tropical medicine and public health, 2015
The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the ...
Usa, Thisyakorn, Chule, Thisyakorn
openaire   +1 more source

Dengue vaccines: preparing to roll back dengue.

Current opinion in investigational drugs (London, England : 2000), 2003
Dengue is an emerging viral pathogen of growing global importance, infecting up to 100 million people annually. Although there have been many efforts over the last six decades to produce a vaccine to combat this infection, few have been able to meet the challenges posed by the unusual interplay between this virus and its human host.
Jacobs, M., Young, P. R.
openaire   +3 more sources

[Dengue vaccine].

Nihon rinsho. Japanese journal of clinical medicine, 2011
Dengue fever is the most important mosquito-borne viral disease in the world, for which preventive vaccines are urgently required. Several strategies have been used for dengue tetravalent vaccine development. Strategies with traditional attenuation, chimerization, engineered attenuation are in the more advanced stages. In addition, inactivated, subunit,
openaire   +1 more source

Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines

Current Treatment Options in Infectious Diseases, 2023
Ashley St John   +2 more
exaly  

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