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Adaptation of Dengue Virus to the Hamster
The American Journal of Tropical Medicine and Hygiene, 1952Summary By serial intracerebral passages, the New Guinea C and Hawaiian strains of dengue virus were adapted to growth in hamsters of 2–5 days of age. Dengue virus should no longer be described, without qualification, as non-pathogenic for the hamster.
G, MEIKLEJOHN, B, ENGLAND, E H, LENNETTE
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Dengue Virus Vaccine Development
2014Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range from asymptomatic to a self-limited febrile illness, dengue fever (DF), to the life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Lauren E, Yauch, Sujan, Shresta
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Molecular virology of dengue virus.
2014This chapter examines the multiple functions of the dengue virus (DENV) genome, not only as a coding molecule for viral protein synthesis but also as a main regulator of viral processes. An overview of the viral life cycle is described, and the recent advances on functions of viral RNA structures, studies on the biogenesis and architecture of ...
Iglesias, Nestor Gabriel +2 more
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Dengue Virus–Mosquito Interactions
Annual Review of Entomology, 2008The mosquito Aedes aegypti is more widely dispersed now than at any time in the past, placing billions of humans at risk of infection with one or more of the four dengue viruses. This review presents and discusses information on mosquito-dengue infection dynamics and describes the prominent role that temperature and rainfall play in controlling dengue ...
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A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
Nature, 2021Ralf Bartenschlager +2 more
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Subversion of Interferon by Dengue Virus
2009Dengue virus is sensed in mammalian cells by Toll-like receptors and DExD/H box RNA helicases, triggering a Type 1 interferon response. Interferon acts upon infected and noninfected cells by stimulating the JAK/STAT signaling pathway resulting in the activation of interferon stimulated genes that lead cells toward the establishment of an antiviral ...
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Novel antibodies defeat dengue virus
Nature Reviews Microbiology, 2015Sarah Crunkhorn
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Dengue virus: epidemiology, biology, and disease aetiology
Canadian Journal of Microbiology, 2021Soumen Bhattacharjee
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Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
Nature Reviews Immunology, 2011Alan L. Rothman
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