Results 191 to 200 of about 161,991 (287)

A diffusion-based framework for designing molecules in flexible protein pockets. [PDF]

Sci Adv
Wang J, Zhang DY, Budakoti S, Dokholyan NV.   +3 more
europepmc   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

BanglaOCT2025: A Population-Specific Fovea-Centric OCT Dataset with Self-Supervised Volumetric Restoration Using Flip-Flop Swin Transformers. [PDF]

Diagnostics (Basel)
Bepery C, Rahaman GMA, Debnath R, Saha S, Islam MS, Abir MEI, Sarker SK.   +6 more
europepmc   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Revolutionizing hyper spectral image denoising: a squeezenet paradigm. [PDF]

Sci Rep
Nachimuthu N, Murugesan R, Dharmalingam M, Prakash G.   +3 more
europepmc   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

A high-performance training-free pipeline for robust random telegraph signal characterization via adaptive wavelet-based denoising and Bayesian digitization methods. [PDF]

Sci Rep
Bai T, Kapoor A, Kim NY.
europepmc   +1 more source

Complexity Analysis of Bubble Plumes in Power Law Fluids Based on Chaos Theory

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT In order to reveal the complexity of the internal flow of bubble plume in power law fluid, the flow characteristics and chaotic characteristics of plume are studied by experiment and theory. The chaotic characteristic parameters (correlation dimension D, K entropy, and Lyapunov exponent λ) of gas velocity under different superficial gas ...
Xin Dong, Chong Dong, Can Xue, Meiheng Peng, Ying Feng, Jianwei Zhang, Yinuo Liu   +6 more
wiley   +1 more source

Inter‐microscope comparability of dental microwear texture data obtained from different optical profilometers: Part I Reproducibility of diet inference using different instruments

The Anatomical Record, EarlyView.
Abstract Dental microwear texture analysis (DMTA) has become a well‐established method for dietary inference and reconstruction in both extant and extinct mammals and other tetrapods. As the volume of available data continues to grow, researchers could benefit from combining published data from various studies to perform meta‐analyses.
Daniela E. Winkler, Mugino O. Kubo
wiley   +1 more source