Results 171 to 180 of about 904,708 (330)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Age-Related Changes as the Primary Driver of Pineal Gland Involution-A Morphological Study in Health and Disease. [PDF]

Int J Mol Sci
Junemann O, Otlyga D, Bukreeva I, Saveliev S.   +3 more
europepmc   +1 more source

Restitution of the Temperature Field Inside a Cylinder of Semitransparent Dense Medium From Directional Intensity Data [PDF]

, 2009
Vital Le Dez, Denis Lemonnier, Hamou Sadat   +2 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Derived UV-Vis Absorbance Spectra for Facile Analysis of Optically Dense Samples. [PDF]

ACS Omega
Panigrahi SK, Tarai M.
europepmc   +1 more source

Linear Stability Effect of Densely Distributed Porous Medium and Coriolis Force on Soret Driven Ferrothermohaline Convection [PDF]

, 2018
R. Sekar, D. Murugan
openalex   +1 more source

Holographic Hadrons in Dense Medium [PDF]

Progress of Theoretical Physics Supplement, 2010
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Synthetic control of implanted engineered liver tissue growth. [PDF]

Sci Adv
Stoddard AE, Kumar V, Tzouanas CN, Hui V, Li J, Jain A, Farrell A, Bhatia SN, Chen CS.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source