Results 121 to 130 of about 610,310 (264)

Single-cell transcriptomic evidence for dense intracortical neuropeptide networks

eLife, 2019
Seeking new insights into the homeostasis, modulation and plasticity of cortical synaptic networks, we have analyzed results from a single-cell RNA-seq study of 22,439 mouse neocortical neurons.
Stephen J Smith, Uygar Sümbül, Lucas T Graybuck, Forrest Collman, Sharmishtaa Seshamani, Rohan Gala, Olga Gliko, Leila Elabbady, Jeremy A Miller, Trygve E Bakken, Jean Rossier, Zizhen Yao, Ed Lein, Hongkui Zeng, Bosiljka Tasic, Michael Hawrylycz   +15 more
doaj   +1 more source

A Sustainable Business Model for a Neutral Host Supporting 5G and beyond (5GB) Ultra-Dense Networks: Challenges, Directions, and Architecture. [PDF]

Sensors (Basel), 2022
Allawi YM, Mohammed AFY, Lee J, Choi SG.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dense Convolutional Binary-Tree Networks for Lung Nodule Classification

IEEE Access, 2018
This paper investigates the problem of benign or malignant diagnosis of pulmonary nodule with original thoracic computed tomography images, and presents a novel end-to-end deep learning architecture named dense convolutional binary-tree network ...
Yijing Liu, Pengyi Hao, Peng Zhang, Xinnan Xu, Jian Wu, Wei Chen   +5 more
doaj   +1 more source

Communities of Dense Weighted Networks [PDF]

Journal of Applied Bioinformatics & Computational Biology, 2018
Complex networks are intrinsically modular. Resolving small modules is particularly difficult when the network is densely connected; wide variation of link-weights invites additional complexities. In this article we present an algorithm to detect community structure in densely connected weighted networks.
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

An Artificial Intelligence-based Handover Triggering and Management Mechanism for 5G Ultra-dense Networks to Improve Handover Authentication

Journal of Telecommunications and Information Technology
The emergence of 5G ultra-dense networks has gained considerable attention, as solutions of this kind enable rapid and intelligent device connectivity, thus ushering in a new era of high-speed communications.
P. Rajesh, A. Vijayalakshmi, Ebenezer Abishek B.   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Shared MPR Sets for Moderately Dense Wireless Multihop Networks

International Journal of Distributed Sensor Networks, 2015
Multipoint relays (MPRs) are used for flooding topology control messages and finding the shortest paths for unicast communications in the optimized link state routing protocol (OLSR).
Teruaki Kitasuka, Shigeaki Tagashira
doaj   +1 more source