Results 191 to 200 of about 50,398 (301)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

open access: yesAdvanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins   +9 more
wiley   +1 more source

Plasma cell mastitis: a comprehensive review of etiological advances and future directions. [PDF]

open access: yesFront Immunol
Xu H   +8 more
europepmc   +1 more source

Janus Photonic Graphics by Stratified Assembly of Two Distinct Colloids

open access: yesAdvanced Functional Materials, EarlyView.
Double‐sided Janus photonic micropatterns with vivid structural colors are fabricated through a single‐step bottom‐up strategy. Density‐driven stratification and depletion‐mediated crystallization of PMMA and PS binary colloids lead to exclusive lattices on opposite surfaces under centrifugal force.
Young Geon Kim   +4 more
wiley   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

open access: yesAdvanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho   +8 more
wiley   +1 more source

Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis. [PDF]

open access: yesNat Commun
Borhan B   +9 more
europepmc   +1 more source

Sustainable Electrochemical Synthesis of High‐Quality MXenes: Mechanistic Insights, Applications, Challenges, and Technological Prospects

open access: yesAdvanced Functional Materials, EarlyView.
Electrochemical etching provides an eco‐friendly alternative to hazardous HF methods for MXene production. This approach facilitates the selective isolation of the A‐layer from MAX phases with tunable surface terminations. Controlling voltage, electrolytes, temperature, and duration enables the optimal structural integrity. Nevertheless, existing scale
Jagdeep Singh   +4 more
wiley   +1 more source

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