Results 261 to 270 of about 7,360,473 (315)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The GAP43 gene in neuroblasts is upregulated in response to cell seeding density. [PDF]

MicroPubl Biol
Wakabayashi M, Nakazawa N.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Skin epidermal and microvascular properties at the sacrum and heel assessed with optical coherence tomography. [PDF]

Skin Pharmacol Physiol
Gordon R, Stevens C, Worsley P, Filinigeri D.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice. [PDF]

Glia
Arzola E, Yu G, Xiong L, Lee D, Wu A, Paruchuri S, Skinner J, Wang M, Zhang B, Mei L, Xiong WC.   +10 more
europepmc   +1 more source

White-tailed deer population declines in a high-prevalence chronic wasting disease region of Arkansas, USA. [PDF]

PLoS One
Gaya HE, Jorge MH, Jorge LA, Ruder MG, D'Angelo GJ, Chandler RB, Chamberlain MJ.   +6 more
europepmc   +1 more source

Optimization of CsSnI₃‑, MASnI₃‑, and MAGeI₃‑Based All-Perovskite Solar Cells for Cost-Effective and Nontoxic Energy Conversion. [PDF]

ACS Omega
Uddin R, Bhowmik S.
europepmc   +1 more source

In vitro evaluation of different implant systems and their influence on primary stability. [PDF]

Sci Rep
Neto OA, Câmara JVF, Schestakow A, Ribeiro AOP, Araujo TT, Sotto-Maior BS.   +5 more
europepmc   +1 more source

Synergies and trade-offs in forest carbon pools: separating universal drivers from forest type-specific controls. [PDF]

Front Plant Sci
Zhou Y, She J, Xiang G, Zhu X.
europepmc   +1 more source