Results 131 to 140 of about 3,935,284 (258)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Data from: High temperature intensifies negative density dependence of fitness in red flour beetles
, 2015 Competition for food, space, or other depletable resources has strong impacts on the fitness of organisms and can lead to a pattern known as negative density dependence, where fitness decreases as population density increases.
Halliday, William D. +2 more
core +1 more source
Ecology and EvolutionAnthropogenic change is reshaping the regulation and stability of animal population dynamics across broad biogeographic gradients. For example, abiotic and biotic interactions can cause gradients in population cycle period and amplitude, but this ...
T. J. Clark‐Wolf +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Introduced herbivores and the Allee effect in animal-pollinated plants
Ecología Austral, 2007 Interspecific interactions can be modulated by the community context in which they occur. In this paper I focus on plant–pollinator interactions and their modulation by introduced herbivores through changes in plant population density. I first develop a
Diego P. Vázquez
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Ecology and EvolutionAvian biodiversity declines are increasingly linked to invasive parasites threatening local bird populations that lack evolved defenses. The level of virulence in these interactions, in turn, influences the parasites' own fitness and drives co ...
Barbara Kofler +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
How density dependence, genetic erosion and the extinction vortex impact evolutionary rescue. [PDF]
Proc Biol Sci, 2023 Nordstrom SW +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source