Results 161 to 170 of about 3,935,284 (258)

Nonparametric Beta Kernel Estimator for Long Memory Time Series [PDF]

The paper introduces a new nonparametric estimator of the spectral density that is given in smoothing the periodogram by the probability density of Beta random variable (Beta kernel).
Van Bellegem, Sébastien, Bouezmarni, Taoufik   +1 more
core  

Sex, density dependence, and urbanization level shape host infection by an obligate endoparasite. [PDF]

PLoS One
MacIvor JS, Hall TCK.
europepmc   +1 more source

Demographic consequences of heterogeneity in conspecific density dependence among mast-fruiting tropical trees. [PDF]

Proc Biol Sci, 2022
O'Brien MJ, Hector A, Kellenberger RT, Maycock CR, Ong R, Philipson CD, Powers JS, Reynolds G, Burslem DFRP.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Density Dependence During Evolutionary Rescue Increases Extinction Risk but Does Not Prevent Adaptation. [PDF]

Ecol Lett
Olazcuaga L, Melbourne BA, Nordstrom SW, Hufbauer RA.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Optimal harvesting of a continuously age-structured population with density dependence. [PDF]

PLoS One
Opmeer M.
europepmc   +1 more source

Density Dependence Influences the Efficacy of Wastewater Remediation by Lemna minor. [PDF]

Plants (Basel), 2021
Walsh É, Coughlan NE, O'Brien S, Jansen MAK, Kuehnhold H.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Density Dependence Promotes Species Coexistence and Provides a Unifying Explanation for Distinct Productivity-Diversity Relationships. [PDF]

Ecol Lett
Xu L, Klausmeier CA, Zakem E.
europepmc   +1 more source