Results 131 to 140 of about 2,072,080 (375)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
New Phase Transitions Driven by Soft Phonon Modes for CsPbBr3: Density Functional Theory Study [PDF]
, 2021 Raouia Ben Sadok +2 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Assessing Density-Functional Theory for Equation-Of-State
Computation, 2018 The last decade has seen a continued development of better experimental techniques to measure equation-of-state (EOS) for various materials. These improvements of both static and shock-compression approaches have increased the accuracy of the EOS and ...
Per Söderlind, David A. Young
doaj +1 more source
Erratum: Energy-density functionals inspired by effective-field theories: Applications to neutron drops [Phys. Rev. C 98, 034319 (2018)] [PDF]
, 2021 J. Bonnard, M. Grasso, Denis Lacroix
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Relativistic Linear Response in Quantum-Electrodynamical Density Functional Theory
Physical Review XWe present the theoretical derivation and numerical implementation of the linear-response equations for relativistic quantum-electrodynamical density functional theory (QEDFT).
Lukas Konecny +4 more
doaj +1 more source
Functional renormalization group and Kohn–Sham scheme in density functional theory
Physics Letters B, 2018 Deriving accurate energy density functional is one of the central problems in condensed matter physics, nuclear physics, and quantum chemistry. We propose a novel method to deduce the energy density functional by combining the idea of the functional ...
Haozhao Liang, Yifei Niu, Tetsuo Hatsuda
doaj +1 more source
Low-energy effective Hamiltonians for correlated electron systems beyond density functional theory [PDF]
, 2017 Motoaki Hirayama +3 more
openalex +1 more source