Results 51 to 60 of about 317,422 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Midwifery-dental intervention to improve oral health : a process evaluation

, 2016
Aim or purpose: The Midwifery Initiated Oral Health–Dental Service (MIOH-DS) program was trialled and found to be effective in improving maternal oral health.
Blinkhorn, Anthony, Farley, Julia (S34642), Srinivas, Ravi (R19096), George, Ajesh (R15339), Bhole, Sameer, Ajwani, Shilpi, Ellis, Sharon, Dahlen, Hannah G. (R13596), Yaacoub, Albert, Johnson, Maree   +9 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Assessment of Dental Age Estimation Using Aspartic Acid Racemization in Human Dentin in Single-Rooted Teeth

Journal of Orofacial Sciences, 2022
Introduction: Dental age estimation has always been a very important and very susceptible subject in forensic science, as it is an essential requirement in living, dead human individual’s remains. Aspartic acid racemization is considered to be one of the
Neelima Dasarathi, Kiran Kumar Kattappagari, Venkata Suresh Ponnuru, Ravi Teja Chitturi Suryaprakash, Arvind Babu Santhosh, Baddam Venkat Ramana Reddy   +5 more
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Perceived Dental Treatment Need Among Older Tanzanian Adults - A Cross-Sectional Study. [PDF]

, 2007
Need perceptions for dental care play a key role as to whether people in general will seek dental care. The aim was to assess the prevalence of perceived need of problem based dental care, dental check-ups and any type of dental care.
Kida, Irene A, Kida Irene A, Anne N Åstrøm, Åstrøm Anne N, Irene A Kida, Astrøm, Anne N   +5 more
core   +1 more source

Foreign body aspiration and ingestion in dental clinic: a seven-year retrospective study [PDF]

, 2022
Background: This retrospective study investigated the incidence rate of accidental foreign body aspiration and ingestion according to patient sex, age, and dental department.
차정열, 허지선, 김기덕, 김기열, 박원서, 정서연   +5 more
core   +1 more source

Life style and risk of development of dental caries in a population of adolescents

Annals of Agricultural and Environmental Medicine, 2014
Introduction. Oxygen is an essential element for sustaining the life of aerobes; however, in certain conditions it may be toxic for these organisms. This is due to so-called reactive oxygen species – ROS.
Dorota Krawczyk, Jerzy Błaszczak, Janusz Borowicz, Maria Mielnik-Błaszczak   +3 more
doaj