Results 91 to 100 of about 1,223,402 (387)

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Association between developmental dental anomalies, early childhood caries and oral hygiene status of 3–5-year-old children in Ile-Ife, Nigeria

BMC Oral Health, 2019
To determine the association between developmental dental anomalies (DDA), early childhood caries (ECC) and oral hygiene status of 3–5-year-old children resident in Ile-Ife, Nigeria. This was a cross-sectional study.
M. Foláyan, Michael Alade, A. Adeniyi, M. El Tantawi, T. Finlayson   +4 more
semanticscholar   +1 more source

Multidisciplinary Approach to Fused Maxillary central Incisors: a Case Report [PDF]

, 2014
Introduction: The fusion of permanent teeth is a development anomaly of dental hard tissue. It may require a hard multidisciplinary approach with orthodontics, endodontics, surgery and prosthetics to solve aesthetic and functional problems.
Cerone V, Gasparro R, Riccitiello F, Sammartino G, Trosino O.   +4 more
core   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Axion Like Particles and the Inverse Seesaw Mechanism [PDF]

, 2015
Light pseudoscalars known as axion like particles (ALPs) may be behind physical phenomena like the Universe transparency to ultra-energetic photons, the soft $\gamma$-ray excess from the Coma cluster, and the 3.5 keV line.
Carvajal, C. D. R., Dias, A. G., Nishi, C. C., Sánchez-Vega, B. L.   +3 more
core   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Prevalence of Radiographically Detectable Non-syndromic Dental Anomalies amongst Orthodontic Patients - A Retrospective Study

Indian Journal of Dental Research
Introduction: Developmental dental anomalies are variations from expected clinical appearance, shape, size, color, contour, number, eruption pattern, and degree of tooth development.
Rahul Koul, Sanjeev Datana, Saugat Ray
doaj   +1 more source

Endodontic management of type IIIB dens invaginatus: An unusual case report

Saudi Endodontic Journal, 2018
Dens invaginatus (DI) is an unusual anomaly of teeth, presumably resulting from an infolding of the dental papilla during tooth development. The root canal treatment of such teeth is arduous because of problems associated with gaining access to the root ...
Afzal Ali, Prahlad Saraf, Jayaprakash Patil   +2 more
doaj   +1 more source

Prevalence of dental agenesis in a sample of Italian orthodontic patients: an epidemiological study

Progress in orthodontics, 2017
The congenital absence of one or more teeth is a dental anomaly that frequently occurs in the world’s population with a wide variability of distribution.
A. Gracco, Serena Zanatta, Filippo Forin Valvecchi, Denis Bignotti, Alessandro Perri, Francesco Baciliero   +5 more
semanticscholar   +1 more source