Results 51 to 60 of about 49,811 (317)
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Dental Anxiety in Patients in Lahore Medical and Dental College: A Cross Sectional Study
Journal of Islamic International Medical College, 2021 Objective: To assess the prevalence and level of dental anxiety in patients reporting to the Outpatient Department in Lahore Medical and Dental College. Study Design: A Cross Sectional Comparative Study.
Fatima Suhaib, Usman Mahmood, Uzair Abu Bakar, Aqib Sohail, Shyreen Liaqat
doaj
Dental anxiety – conditions, models, therapy
Journal of Medical Science, 2018 Dental anxiety is a condition suffered by many dental patients. It causes psychological discomfort and avoidance of dental appointments, which in turn may lead to oral health issues.
Małgorzata Sobol-Kwapińska +3 more
doaj +1 more source
Dentistry and Medical Research, 2023 Background: The demand of excellence and proficiency among professionals is a threat to vocational well-being. The anxiety inherited by dental students is reflected through poor physical and psychological health, loss of interest leading absenteeism, and
Deepak Gurung +2 more
doaj +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Behaviour and Anxiety Management of Paediatric Dental Patients through Virtual Reality: A Randomised Clinical Trial [PDF]
, 2021 Cristina Gómez‐Polo +4 more
openalex +1 more source
Reducing Anxiety for Dental Visits [PDF]
, 2019 This work addresses children’s (under 6 years of age) fear and apprehension to visit dental clinics. We present a bespoke interactive Virtual Reality reproduction of the physical dental clinic, augmented with virtual characters and enriched with gamification style information for a richer user experience.
Kathryn Elizabeth Jones +9 more
openaire +1 more source
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Effectiveness of and Patient’s Satisfaction with Dental Emergency Unit in Pitié Salpêtrière Hospital (Paris), Focusing on Pain and Anxiety [PDF]
, 2022 Grégoire Demeestere +4 more
openalex +1 more source
Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Advanced Science, EarlyView.DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin +15 more
wiley +1 more source